Maternal air pollution exposure and congenital heart defects in offspring: A systematic review and meta-analysis.
Air Pollutants
/ analysis
Air Pollution
/ analysis
Carbon Monoxide
/ analysis
Environmental Exposure
/ analysis
Female
Heart Defects, Congenital
/ chemically induced
Humans
Maternal Exposure
/ statistics & numerical data
Nitrogen Dioxide
/ analysis
Odds Ratio
Ozone
/ analysis
Particulate Matter
/ analysis
Air pollution
Congenital heart defects
Meta-analysis
Systematic review
Journal
Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
06
01
2020
revised:
27
03
2020
accepted:
30
03
2020
pubmed:
13
4
2020
medline:
1
7
2020
entrez:
13
4
2020
Statut:
ppublish
Résumé
Congenital heart defects (CHDs) has a multifactorial causation with a strong genetic component and many environmental triggers. Emerging body of empirical studies suggest that air pollution is an important contributor to the development of CHDs, however, there still remains some controversy over the current evidence, and to the authors' knowledge, no studies have reviewed the most recent evidence. We performed a systematic review and meta-analysis of epidemiological literature to investigate the relationship between maternal air pollution exposure and CHDs risk in offspring. The presence of heterogeneity and publication bias across available studies were also examined. An extensive literature search of epidemiological studies pertaining to air pollution and CHDs, published in English language, until August 1, 2019 was conducted. Summary risk estimates of pollution-outcome combinations were calculated for i) risk per specific increment of concentration and ii) risk at high versus low exposure level in each study using fixed-effect model or random-effects model. A total of 26 studies were finally included. In the meta-analyses, high versus low carbon monoxide (CO) exposure was associated with an increased risk of tetralogy of Fallot [odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.04-1.41], yet particulate matter ≤ 5 μm (PM The summary effect estimates from this study suggest statistically significant associations between increased risk of specific CHDs subtypes and PM
Sections du résumé
BACKGROUND
BACKGROUND
Congenital heart defects (CHDs) has a multifactorial causation with a strong genetic component and many environmental triggers. Emerging body of empirical studies suggest that air pollution is an important contributor to the development of CHDs, however, there still remains some controversy over the current evidence, and to the authors' knowledge, no studies have reviewed the most recent evidence.
OBJECTIVES
OBJECTIVE
We performed a systematic review and meta-analysis of epidemiological literature to investigate the relationship between maternal air pollution exposure and CHDs risk in offspring. The presence of heterogeneity and publication bias across available studies were also examined.
METHODS
METHODS
An extensive literature search of epidemiological studies pertaining to air pollution and CHDs, published in English language, until August 1, 2019 was conducted. Summary risk estimates of pollution-outcome combinations were calculated for i) risk per specific increment of concentration and ii) risk at high versus low exposure level in each study using fixed-effect model or random-effects model.
RESULTS
RESULTS
A total of 26 studies were finally included. In the meta-analyses, high versus low carbon monoxide (CO) exposure was associated with an increased risk of tetralogy of Fallot [odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.04-1.41], yet particulate matter ≤ 5 μm (PM
CONCLUSIONS
CONCLUSIONS
The summary effect estimates from this study suggest statistically significant associations between increased risk of specific CHDs subtypes and PM
Identifiants
pubmed: 32278917
pii: S0045-6535(20)30861-4
doi: 10.1016/j.chemosphere.2020.126668
pii:
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Ozone
66H7ZZK23N
Carbon Monoxide
7U1EE4V452
Nitrogen Dioxide
S7G510RUBH
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
126668Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.