The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.
birth weight
neonate
offspring
pregnancy
preterm labor
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
11
03
2020
revised:
30
03
2020
accepted:
02
04
2020
pubmed:
13
4
2020
medline:
21
10
2020
entrez:
13
4
2020
Statut:
ppublish
Résumé
Women who conceive at 35 years of age or older, commonly known as advanced maternal age, have a higher risk of facing parturition complications and their children have an increased risk of developing diseases later in life. However, the immunological mechanisms underlying these pathological processes have yet to be established. To fill this gap in knowledge, using a murine model and immunophenotyping, we determined the effect of advanced maternal age on the main cellular branch of adaptive immunity, T cells, at the maternal-fetal interface and in the offspring. We report that advanced maternal age impaired the process of labor at term, inducing dystocia and delaying the timing of delivery. Advanced maternal age diminished the number of specific proinflammatory T-cell subsets [T helper type 1 (Th1): CD4
Identifiants
pubmed: 32279324
doi: 10.1111/cei.13437
pmc: PMC7290081
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-75Subventions
Organisme : NICHD NIH HHS
ID : HHSN275201300006C
Pays : United States
Informations de copyright
© 2020 British Society for Immunology.
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