Minimum dose rate estimation for pulsed FLASH radiotherapy: A dimensional analysis.
FLASH RT
diffusion process
dose rate effect
hypoxia
oxygen effect
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
30
12
2019
revised:
19
03
2020
accepted:
06
04
2020
pubmed:
13
4
2020
medline:
15
5
2021
entrez:
13
4
2020
Statut:
ppublish
Résumé
To provide an order of magnitude estimate of the minimum dose rate ( In this study, we postulate that radiation-induced transient hypoxia inside normal tissue cells during FLASH RT results in better normal tissue sparing over conventional dose rate radiotherapy. We divide the process of cell irradiation by an ultra-short radiation pulse into three sequential phases: (a) The radiation pulse interacts with the normal tissue cells and produces radiation-induced species. (b) The radiation-induced species react with oxygen molecules and reduce the cell environmental oxygen concentration ( The estimated The
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3243-3249Informations de copyright
© 2020 American Association of Physicists in Medicine.
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