Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
breast cancer
clear cell carcinoma
immunotherapy
molecular profiling
targeted therapy
Journal
The breast journal
ISSN: 1524-4741
Titre abrégé: Breast J
Pays: United States
ID NLM: 9505539
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
13
03
2020
accepted:
27
03
2020
pubmed:
13
4
2020
medline:
22
6
2021
entrez:
13
4
2020
Statut:
ppublish
Résumé
We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell carcinomas that were diagnosed in female patients (mean age: 53.4 years; range: 31-69 years). Based on our findings, we conclude that the majority of clear cell carcinomas are ER/PR positive and consequently amenable to anti-ER treatment modalities. A subset of clear cell carcinomas also harbored alterations in PIK3CA/PTEN/AKT pathway, particularly PTEN, indicating a potential benefit of PI3K/Akt/mTOR inhibitors. The status of I-O biomarkers in clear cell carcinomas indicates a limited therapeutic benefit of immune checkpoint inhibitors (against PD-1/PD-L1).
Identifiants
pubmed: 32279409
doi: 10.1111/tbj.13842
pmc: PMC7586831
doi:
Substances chimiques
Biomarkers
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1781-1783Informations de copyright
© 2020 The Authors. The Breast Journal published by Wiley Periodicals LLC.
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