Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics.

Aged Aged, 80 and over Alzheimer Disease / diagnosis Cognition Female Humans Magnetoencephalography Male Middle Aged Molecular Imaging Occipital Lobe / physiopathology Parietal Lobe / physiopathology Positron-Emission Tomography Protein Aggregation, Pathological Synaptic Transmission tau Proteins / metabolism
Alzheimer's disease Connectivity Graph theory MEG PET Tau

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
08 2020
Historique:
received: 17 12 2018
revised: 03 02 2020
accepted: 10 03 2020
pubmed: 14 4 2020
medline: 20 11 2020
entrez: 14 4 2020
Statut: ppublish

Résumé

Understanding the role of Tau protein aggregation in the pathogenesis of Alzheimer's disease is critical for the development of new Tau-based therapeutic strategies to slow or prevent dementia. We tested the hypothesis that Tau pathology is associated with functional organization of widespread neurophysiological networks. We used electro-magnetoencephalography with [

Identifiants

DOI: 10.1016/j.neurobiolaging.2020.03.009 PMID: 32280029 PMC: PMC7269692
pubmed: 32280029
pii: S0197-4580(20)30086-5
doi: 10.1016/j.neurobiolaging.2020.03.009
pmc: PMC7269692
mid: EMS86300
pii:
doi:

Substances chimiques

tau Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

141-152

Subventions

Organisme : Medical Research Council
ID : SUAG/010 RG91365
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00005/12
Pays : United Kingdom
Organisme : Medical Research Council
ID : SUAG/004 RG91365
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106183/Z/14/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103838
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203139/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N029941/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K005464/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00005/8
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H008217/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U105597119
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Références

Acta Neuropathol. 2014 May;127(5):667-83
pubmed: 24531916
EJNMMI Res. 2018 Mar 2;8(1):19
pubmed: 29500717
Neurobiol Aging. 2005 Feb;26(2):165-71
pubmed: 15582746
J Alzheimers Dis. 2010;19(3):859-71
pubmed: 20157242
Neurology. 2016 Mar 22;86(12):1112-9
pubmed: 26888983
Int J Neural Syst. 2017 Dec;27(8):1750041
pubmed: 28958179
Brain. 2009 Jan;132(Pt 1):213-24
pubmed: 18952674
Brain Connect. 2016 Feb;6(1):1-8
pubmed: 26414628
PLoS One. 2015 Oct 13;10(10):e0140311
pubmed: 26461913
Neuroimage. 2004 Sep;23(1):84-97
pubmed: 15325355
J Neurosci. 2016 Nov 30;36(48):12083-12094
pubmed: 27903719
Hum Brain Mapp. 2014 May;35(5):2383-93
pubmed: 24039033
Brain. 2018 Feb 1;141(2):550-567
pubmed: 29293892
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6040-5
pubmed: 20304792
Neuroimage. 2010 Jan 1;49(1):668-93
pubmed: 19573607
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130144
pubmed: 24298146
BMC Neurosci. 2009 Aug 21;10:101
pubmed: 19698093
Neuroimage. 2017 Feb 15;147:669-677
pubmed: 28039094
Neuroimage. 2012 Aug 15;62(2):1121-30
pubmed: 22248578
Alzheimers Dement (Amst). 2019 Jun 14;11:450-462
pubmed: 31431918
Brain. 2018 May 1;141(5):1517-1528
pubmed: 29538647
Neuroimage. 2004 May;22(1):57-67
pubmed: 15109997
Cell Stem Cell. 2009 Dec 4;5(6):634-45
pubmed: 19951691
Neuroimage. 2015 Aug 15;117:439-48
pubmed: 25862259
Hum Brain Mapp. 2015 Mar;36(3):1217-32
pubmed: 25411150
Neuroimage. 2009 Aug 15;47(2):581-9
pubmed: 19398023
Trends Mol Med. 2005 Apr;11(4):170-6
pubmed: 15823755
Neuron. 1999 Sep;24(1):49-65, 111-25
pubmed: 10677026
Neuroimage Clin. 2015 Jun 30;8:660-6
pubmed: 26288751
J Clin Neurophysiol. 2002 Dec;19(6):562-74
pubmed: 12488788
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Hum Brain Mapp. 2002 Nov;17(3):143-55
pubmed: 12391568
ISRN Geriatr. 2013;2013:
pubmed: 25414852
Clin Neurophysiol. 2000 Nov;111(11):1961-7
pubmed: 11068230
Neuron. 2016 Mar 2;89(5):971-982
pubmed: 26938442
Nature. 1999 Feb 4;397(6718):430-3
pubmed: 9989408
Cereb Cortex. 2016 Sep;26(9):3851-65
pubmed: 26315689
J Neurosci. 2014 Aug 20;34(34):11416-25
pubmed: 25143621
Sci Rep. 2017 Jul 26;7(1):6517
pubmed: 28747760
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Hum Brain Mapp. 2015 Jun;36(6):2248-69
pubmed: 25727740
J Alzheimers Dis. 2017;60(1):283-293
pubmed: 28800330
Neurobiol Aging. 2016 May;41:122-129
pubmed: 27103525
Neuroimage. 2012 Feb 15;59(4):3085-93
pubmed: 22154957
Clin Neurophysiol. 2006 May;117(5):1113-29
pubmed: 16564740
Arch Neurol. 2011 Sep;68(9):1131-6
pubmed: 21555604
Clin Neurophysiol. 2009 May;120(5):910-5
pubmed: 19386543
Neurobiol Aging. 2017 Sep;57:133-142
pubmed: 28646686
Neuroimage. 2015 Sep;118:456-67
pubmed: 26049146
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
Brain Imaging Behav. 2017 Oct;11(5):1290-1301
pubmed: 27714554
Brain. 2017 Mar 1;140(3):781-791
pubmed: 28122879
Eur J Nucl Med Mol Imaging. 2019 Dec;46(13):2819-2830
pubmed: 31292699
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Neurobiol Aging. 2000 Jul-Aug;21(4):533-40
pubmed: 10924766
J Neurosci. 2007 Mar 14;27(11):2866-75
pubmed: 17360908
Cell. 2012 Apr 27;149(3):708-21
pubmed: 22541439
Brain Connect. 2012;2(2):45-55
pubmed: 22480296
J Neurosci. 2016 Mar 16;36(11):3115-26
pubmed: 26985024
J Alzheimers Dis. 2016 Dec 6;55(3):1195-1205
pubmed: 27792014
Neurology. 2013 Jan 22;80(4):359-65
pubmed: 23255822
Ann Neurol. 2016 Jan;79(1):110-9
pubmed: 26505746
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19518-23
pubmed: 17159150
Neurobiol Aging. 1996 Jul-Aug;17(4):523-6
pubmed: 8832625
Neuroscience. 2016 Mar 1;316:143-50
pubmed: 26724581
PLoS One. 2010 Nov 01;5(11):e13788
pubmed: 21072180
J Neurosci. 2015 Jul 15;35(28):10325-30
pubmed: 26180207
IEEE Trans Med Imaging. 1997 Apr;16(2):176-86
pubmed: 9101327
Brain. 2017 May 1;140(5):1466-1485
pubmed: 28334883
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Med Image Comput Comput Assist Interv. 2012;15(Pt 3):305-12
pubmed: 23286144
Neurobiol Aging. 2014 Apr;35(4):757-68
pubmed: 24216223
Neurobiol Dis. 2016 Jul;91:105-23
pubmed: 26949217
Comput Methods Programs Biomed. 2008 May;90(2):137-47
pubmed: 18249462
Neuroimage. 2009 Feb 1;44(3):715-23
pubmed: 19027073
Neuroimage. 2012 Jan 16;59(2):1404-12
pubmed: 21888983
Neurobiol Aging. 2016 Dec;48:153-160
pubmed: 27697694
Brain. 2016 May;139(Pt 5):1551-67
pubmed: 26962052
PLoS Comput Biol. 2009 May;5(5):e1000381
pubmed: 19412534
Neuroimage. 2016 Sep;138:284-293
pubmed: 27262239
PLoS Comput Biol. 2007 Feb 2;3(2):e17
pubmed: 17274684
PLoS One. 2011;6(7):e21976
pubmed: 21818285
Cell. 2010 Aug 6;142(3):387-97
pubmed: 20655099
Sci Transl Med. 2016 May 11;8(338):338ra66
pubmed: 27169802
Chaos. 2009 Jun;19(2):023119
pubmed: 19566254
Brain. 2018 Feb 1;141(2):568-581
pubmed: 29315361
Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13170-5
pubmed: 17670949
Neurobiol Aging. 2014 Jan;35(1):42-54
pubmed: 23942392
Alzheimers Dement. 2017 Nov;13(11):1261-1269
pubmed: 28366797
Brain. 2014 Aug;137(Pt 8):2382-95
pubmed: 25057133
Brain. 2015 May;138(Pt 5):1370-81
pubmed: 25805643
Hum Brain Mapp. 2008 Dec;29(12):1368-78
pubmed: 18064590
Neuron. 2009 Jun 25;62(6):788-801
pubmed: 19555648
Neuron. 2013 Dec 4;80(5):1112-28
pubmed: 24314724
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Hum Brain Mapp. 2016 Jan;37(1):20-34
pubmed: 26503502
Cereb Cortex. 2007 Jan;17(1):92-9
pubmed: 16452642
Int J Psychophysiol. 1996 Nov;24(1-2):101-12
pubmed: 8978437
PLoS Comput Biol. 2008 Jun 27;4(6):e1000100
pubmed: 18584043
Science. 2004 May 14;304(5673):1021-4
pubmed: 15143284
PLoS One. 2014 Feb 03;9(2):e88202
pubmed: 24498438
J Neurosci. 2004 Nov 17;24(46):10369-78
pubmed: 15548651
PLoS One. 2010 Apr 27;5(4):e10232
pubmed: 20436911
Nature. 2001 Mar 8;410(6825):268-76
pubmed: 11258382
Neurobiol Aging. 2012 Feb;33(2):427.e15-30
pubmed: 21272960
Int J Psychophysiol. 2001 Jan;39(2-3):241-8
pubmed: 11163901
Cereb Cortex. 2014 Jun;24(6):1422-35
pubmed: 23314940
Brain. 2018 Aug 1;141(8):2500-2510
pubmed: 30060017
Neuroimage Clin. 2018 May 22;20:128-152
pubmed: 30094163
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499
Neuron. 2006 Dec 7;52(5):831-43
pubmed: 17145504

Auteurs

Ece Kocagoncu (E)

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK. Electronic address: ek390@cam.ac.uk.

Andrew Quinn (A)

Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK; Department of Psychiatry, University of Oxford, Oxford, UK.

Azadeh Firouzian (A)

Invicro LLC, London, UK.

Elisa Cooper (E)

MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Andrea Greve (A)

MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Roger Gunn (R)

Invicro LLC, London, UK; Department of Medicine, Imperial College London, London, UK; Department of Engineering Science, University of Oxford, Oxford, UK.

Gary Green (G)

Department of Psychology, University of York, York, UK.

Mark W Woolrich (MW)

Oxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK; Department of Psychiatry, University of Oxford, Oxford, UK.

Richard N Henson (RN)

MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK; Department of Psychiatry, University of Cambridge, Cambridge, UK.

Simon Lovestone (S)

Department of Psychiatry, University of Oxford, Oxford, UK.

James B Rowe (JB)

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Techniques d'investigation › Magnétométrie › Magnétoencéphalographie › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Imagerie moléculaire › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe occipital › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe pariétal › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Agrégation pathologique de protéines › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Tau pathology in early Alzheimer's disease is...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Tau pathology in early Alzheimer's disease is...