Mitochondria-Modulating Porous Se@SiO
Acute Lung Injury
/ chemically induced
Animals
Antioxidants
/ chemistry
Cell Line
Cytoprotection
Disease Models, Animal
Epithelial Cells
/ metabolism
Humans
Lipopolysaccharides
/ toxicity
Lung
/ drug effects
Mice
Mitochondria
/ drug effects
Nanoparticles
/ chemistry
Oxidation-Reduction
Oxidative Stress
/ drug effects
Porosity
Selenium
/ chemistry
Silicon Dioxide
/ chemistry
acute lung injury
anti-inflammation
anti-oxidative injury
mitochondrial dysfunction
porous Se@SiO2 nanoparticles
Journal
International journal of nanomedicine
ISSN: 1178-2013
Titre abrégé: Int J Nanomedicine
Pays: New Zealand
ID NLM: 101263847
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
11
2019
accepted:
10
03
2020
entrez:
14
4
2020
pubmed:
14
4
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Mitochondrial dysfunction played a vital role in the pathogenesis of various diseases, including acute lung injury (ALI). However, few strategies targeting mitochondria were developed in treating ALI. Recently, we fabricated a porous Se@SiO The protective effect of Se@SiO This study demonstrated that Se@SiO This study brought new insights into mitochondria-targeting bioactive NPs, with application potential in curing ALI or other human mitochondria-related disorders.
Sections du résumé
BACKGROUND
BACKGROUND
Mitochondrial dysfunction played a vital role in the pathogenesis of various diseases, including acute lung injury (ALI). However, few strategies targeting mitochondria were developed in treating ALI. Recently, we fabricated a porous Se@SiO
METHODS
METHODS
The protective effect of Se@SiO
RESULTS
RESULTS
This study demonstrated that Se@SiO
CONCLUSION
CONCLUSIONS
This study brought new insights into mitochondria-targeting bioactive NPs, with application potential in curing ALI or other human mitochondria-related disorders.
Identifiants
pubmed: 32280221
doi: 10.2147/IJN.S240301
pii: 240301
pmc: PMC7127826
doi:
Substances chimiques
Antioxidants
0
Lipopolysaccharides
0
Silicon Dioxide
7631-86-9
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2287-2302Informations de copyright
© 2020 Wang et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest in this work.
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