Regression of Peritubular Capillaries Coincides with Angiogenesis and Renal Cyst Growth in Experimental Polycystic Kidney Disease.
LPK
Lewis polycystic kidney
jck
juvenile cystic kidney
peritubular capillary loss
renal vasculature
Journal
International journal of nephrology and renovascular disease
ISSN: 1178-7058
Titre abrégé: Int J Nephrol Renovasc Dis
Pays: New Zealand
ID NLM: 101550217
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
11
2019
accepted:
06
03
2020
entrez:
14
4
2020
pubmed:
14
4
2020
medline:
14
4
2020
Statut:
epublish
Résumé
The natural history of the renal microvasculature changes in PKD is not known. The aim of this study was to test the hypothesis that angiogenesis is coupled with kidney cyst expansion, and the loss of peritubular capillary networks precedes the onset of interstitial fibrosis. The renal microvasculature (RECA-1 and CD34) was evaluated in groups of Lewis polycystic kidney (LPK) rats and juvenile cystic kidney ( In LPK rats, the loss of peritubular capillaries occurred in early-stage disease and paralleled cyst formation whereas in Regression of peritubular capillaries and disruption of vasa recta occur in parallel with angiogenesis and the progressive enlargement of kidney cysts. These data suggest that the regrowth of peritubular capillaries together with inhibition of angiogenesis are potential strategies to be considered in the treatment of PKD.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The natural history of the renal microvasculature changes in PKD is not known. The aim of this study was to test the hypothesis that angiogenesis is coupled with kidney cyst expansion, and the loss of peritubular capillary networks precedes the onset of interstitial fibrosis.
METHODS
METHODS
The renal microvasculature (RECA-1 and CD34) was evaluated in groups of Lewis polycystic kidney (LPK) rats and juvenile cystic kidney (
RESULTS
RESULTS
In LPK rats, the loss of peritubular capillaries occurred in early-stage disease and paralleled cyst formation whereas in
CONCLUSION
CONCLUSIONS
Regression of peritubular capillaries and disruption of vasa recta occur in parallel with angiogenesis and the progressive enlargement of kidney cysts. These data suggest that the regrowth of peritubular capillaries together with inhibition of angiogenesis are potential strategies to be considered in the treatment of PKD.
Identifiants
pubmed: 32280260
doi: 10.2147/IJNRD.S238767
pii: 238767
pmc: PMC7132028
doi:
Types de publication
Journal Article
Langues
eng
Pagination
53-64Informations de copyright
© 2020 O’Brien et al.
Déclaration de conflit d'intérêts
Gopala Rangan reports grants from Danone Nutricia Research and Otsuka Australia, outside the submitted work. The authors report no other conflicts of interest.
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