Respiratory Muscle Training Improves Functional Outcomes and Reduces Fatigue in Patients with Myasthenia Gravis: A Single-Center Hospital-Based Prospective Study.
Adult
Aged
Breathing Exercises
/ instrumentation
Fatigue
/ therapy
Female
Forced Expiratory Volume
Hospitals
Humans
Lung
/ physiopathology
Male
Middle Aged
Muscle Fatigue
Myasthenia Gravis
/ complications
Patients
Prospective Studies
Respiratory Function Tests
Respiratory Muscles
Tidal Volume
Vital Capacity
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
12
2019
revised:
17
02
2020
accepted:
09
03
2020
entrez:
14
4
2020
pubmed:
14
4
2020
medline:
8
1
2021
Statut:
epublish
Résumé
Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG. Eighteen patients with mild to moderate MG participated in this study. The training group underwent home-based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12-week RMT. The 12-week RMT significantly increased forced vital capacity (FVC) from 77.9 ± 12.6% to 83.8 ± 17.7% ( The home-based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short-term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.
Sections du résumé
BACKGROUND
BACKGROUND
Myasthenia gravis (MG) is an immune-mediated disorder characterized by muscle fatigue and fluctuating weakness. Impairment in respiratory strength and endurance has been described in patients with generalized MG. We tested the hypothesis that respiratory muscle training (RMT) can improve functional outcomes and reduce fatigue in patients with MG.
METHODS
METHODS
Eighteen patients with mild to moderate MG participated in this study. The training group underwent home-based RMT three times a week for 12 weeks. Sixteen patients with MG without RMT were enrolled as a disease control group. Lung function, autonomic testing, Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), and functional outcome measurement by using quantitative myasthenia gravis (QMG) score and myasthenia gravis composite (MGC) scale were measured before and after the 12-week RMT.
RESULTS
RESULTS
The 12-week RMT significantly increased forced vital capacity (FVC) from 77.9 ± 12.6% to 83.8 ± 17.7% (
CONCLUSION
CONCLUSIONS
The home-based RMT is an effective pulmonary function training for MG patients. The RMT can not only improve short-term outcomes but also reduce fatigue in patients with mild to moderate generalized MG.
Identifiants
pubmed: 32280685
doi: 10.1155/2020/2923907
pmc: PMC7114765
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2923907Informations de copyright
Copyright © 2020 Che-Wei Hsu et al.
Déclaration de conflit d'intérêts
None of the authors has any commercial association, such as consultancies, stock ownership, or other equity interests or patent-licensing arrangements.
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