Additive manufacturing of biodegradable porous orthopaedic screw.
3D printing
Biodegradable
Orthopaedic screws
Porous screws
Journal
Bioactive materials
ISSN: 2452-199X
Titre abrégé: Bioact Mater
Pays: China
ID NLM: 101685294
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
24
10
2019
revised:
11
03
2020
accepted:
18
03
2020
entrez:
14
4
2020
pubmed:
14
4
2020
medline:
14
4
2020
Statut:
epublish
Résumé
Advent of additive manufacturing in biomedical field has nurtured fabrication of complex, customizable and reproducible orthopaedic implants. Layer-by-layer deposition of biodegradable polymer employed in development of porous orthopaedic screws promises gradual dissolution and complete metabolic resorption thereby overcoming the limitations of conventional metallic screws. In the present study, screws with different pore sizes (916 × 918 μm to 254 × 146 μm) were 3D printed at 200 μm layer height by varying printing parameters such as print speed, fill density and travel speed to augment the bone ingrowth. Micro-CT analysis and scanning electron micrographs of screws with 45% fill density confirmed porous interconnections (40.1%) and optimal pore size (259 × 207 × 200 μm) without compromising the mechanical strength (24.58 ± 1.36 MPa). Due to the open pore structure, the 3D printed screws showed increased weight gain due to the deposition of calcium when incubated in simulated body fluid. Osteoblast-like cells attached on screw and infiltrated into the pores over 14 days of
Identifiants
pubmed: 32280835
doi: 10.1016/j.bioactmat.2020.03.009
pii: S2452-199X(20)30049-9
pmc: PMC7139166
doi:
Types de publication
Journal Article
Langues
eng
Pagination
458-467Informations de copyright
© 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
Déclaration de conflit d'intérêts
Authors have no conflict of interest.
Références
RSC Adv. 2018 Jul 16;8(44):25210-25227
pubmed: 35542139
Mater Sci Eng C Mater Biol Appl. 2020 Apr;109:110423
pubmed: 32228966
Oncol Lett. 2017 Nov;14(5):5695-5702
pubmed: 29113197
J Foot Ankle Surg. 2005 Mar-Apr;44(2):144-51
pubmed: 15768364
Nat Rev Rheumatol. 2015 Jan;11(1):45-54
pubmed: 25266456
J Oral Maxillofac Surg. 2007 Nov;65(11):2142-7
pubmed: 17954306
ACS Appl Mater Interfaces. 2017 Nov 15;9(45):39235-39248
pubmed: 29058878
Adv Drug Deliv Rev. 2018 Jul;132:252-269
pubmed: 30053441
J Musculoskelet Neuronal Interact. 2018 Sep 1;18(3):375-381
pubmed: 30179215
PLoS One. 2015 Oct 14;10(10):e0140354
pubmed: 26466309
Acta Orthop Scand. 1994 Jun;65(3):246-52
pubmed: 8042473
Tissue Eng Part A. 2012 Jul;18(13-14):1376-88
pubmed: 22401817
Knee Surg Sports Traumatol Arthrosc. 1997;5(4):217-21
pubmed: 9430570
Am J Sports Med. 1998 Jan-Feb;26(1):119-26
pubmed: 9474412
Biomaterials. 2005 Sep;26(27):5474-91
pubmed: 15860204
J Biomed Mater Res A. 2006 Sep 1;78(3):481-90
pubmed: 16721798
J Res Natl Inst Stand Technol. 2014 Sep 16;119:494-528
pubmed: 26601041
J Craniomaxillofac Surg. 2014 Dec;42(8):1877-84
pubmed: 25175080
Arthroscopy. 2005 Feb;21(2):147-51
pubmed: 15689862
J Mater Sci Mater Med. 2008 Aug;19(8):2781-90
pubmed: 18305907
J Orthop Res. 1989;7(3):307-15
pubmed: 2649648
Med J Armed Forces India. 1994 Jan;50(1):10-14
pubmed: 28769152
Patient Saf Surg. 2017 Mar 20;11:6
pubmed: 28321265
J Biomater Sci Polym Ed. 2001;12(1):107-24
pubmed: 11334185
Int J Nanomedicine. 2016 Jul 13;11:3179-89
pubmed: 27471385
P T. 2014 Oct;39(10):704-11
pubmed: 25336867
World J Orthop. 2016 Mar 18;7(3):171-81
pubmed: 27004165
Knee Surg Sports Traumatol Arthrosc. 2008 Dec;16(12):1080-6
pubmed: 18762911
Nat Commun. 2014 Mar 04;5:3385
pubmed: 24594992
Biomaterials. 1995 Jan;16(1):25-31
pubmed: 7718688
Acta Biomater. 2015 May;18:262-9
pubmed: 25712384
Nat Mater. 2005 Jul;4(7):518-24
pubmed: 16003400
Sci Rep. 2017 Jan 10;7:40369
pubmed: 28071744
J Funct Biomater. 2019 Apr 01;10(2):
pubmed: 30939719