Features and outcome of AIH patients without elevation of IgG.

AIH, autoimmune hepatitis ALP, alkaline phosphatase ALT, alanine aminotransferase AMA, anti-mitochondrial antibody ANA, anti-nuclear antibody AST, aspartate aminotransferase Anti-SLA/LP, anti-soluble liver antigen and anti-liver-pancreas antibodies INR, international normalized ratio LKM, liver kidney microsomal antigen SMA, smooth muscle antibody autoimmune hepatitis drug withdrawal hypergammaglobulinemia immunoglobulin G immunoglobulins

Journal

JHEP reports : innovation in hepatology
ISSN: 2589-5559
Titre abrégé: JHEP Rep
Pays: Netherlands
ID NLM: 101761237

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 30 12 2019
revised: 28 01 2020
accepted: 31 01 2020
entrez: 14 4 2020
pubmed: 14 4 2020
medline: 14 4 2020
Statut: epublish

Résumé

High IgG levels are considered a hallmark of autoimmune hepatitis (AIH). A subgroup of patients with AIH has IgG within the normal range despite evidence of clinical disease activity. The clinical significance of this biomarker has not been explored. In a European multicentre study we compared biochemical, clinical and histological features from patients with AIH and normal IgG-values at diagnosis to an age- and sex-matched control group of patients with typical AIH presenting with elevated IgG. Data were assessed at diagnosis, after 12 months of therapy and at last follow-up. Out of 1,318 patients with AIH, 130 (10%) had normal IgG at presentation. Histological and biochemical parameters at diagnosis, as well as treatment response, showed no difference between groups. Stable remission off treatment was achieved more commonly in the normal IgG group than in the typical AIH group (24 Compared to AIH with typical biochemical features, patients with normal IgG levels at diagnosis (i) show similar biochemical, serological and histological features and comparable treatment response, (ii) appear to lack the selective elevation of serum IgG levels observed in typical active AIH disease, (iii) may represent a subgroup with a higher chance of successful drug withdrawal. A characteristic feature of autoimmune hepatitis (AIH) is an elevation of immunoglobulin G (IgG), which is therefore used as a major diagnostic criterion, as well as to monitor treatment response. Nevertheless, normal IgG does not preclude the diagnosis of AIH. Therefore, we herein assessed the features of patients with AIH and normal IgG in a large multicentre study. This study demonstrates that about 10% of all patients with AIH have normal IgG; these patients are indistinguishable from other patients with AIH with respect to biochemical markers, liver histology, disease severity and treatment response, but might represent a subgroup with a higher chance of remission after drug withdrawal.

Sections du résumé

BACKGROUND & AIMS OBJECTIVE
High IgG levels are considered a hallmark of autoimmune hepatitis (AIH). A subgroup of patients with AIH has IgG within the normal range despite evidence of clinical disease activity. The clinical significance of this biomarker has not been explored.
METHODS METHODS
In a European multicentre study we compared biochemical, clinical and histological features from patients with AIH and normal IgG-values at diagnosis to an age- and sex-matched control group of patients with typical AIH presenting with elevated IgG. Data were assessed at diagnosis, after 12 months of therapy and at last follow-up.
RESULTS RESULTS
Out of 1,318 patients with AIH, 130 (10%) had normal IgG at presentation. Histological and biochemical parameters at diagnosis, as well as treatment response, showed no difference between groups. Stable remission off treatment was achieved more commonly in the normal IgG group than in the typical AIH group (24
CONCLUSIONS CONCLUSIONS
Compared to AIH with typical biochemical features, patients with normal IgG levels at diagnosis (i) show similar biochemical, serological and histological features and comparable treatment response, (ii) appear to lack the selective elevation of serum IgG levels observed in typical active AIH disease, (iii) may represent a subgroup with a higher chance of successful drug withdrawal.
LAY SUMMARY BACKGROUND
A characteristic feature of autoimmune hepatitis (AIH) is an elevation of immunoglobulin G (IgG), which is therefore used as a major diagnostic criterion, as well as to monitor treatment response. Nevertheless, normal IgG does not preclude the diagnosis of AIH. Therefore, we herein assessed the features of patients with AIH and normal IgG in a large multicentre study. This study demonstrates that about 10% of all patients with AIH have normal IgG; these patients are indistinguishable from other patients with AIH with respect to biochemical markers, liver histology, disease severity and treatment response, but might represent a subgroup with a higher chance of remission after drug withdrawal.

Identifiants

pubmed: 32280942
doi: 10.1016/j.jhepr.2020.100094
pii: S2589-5559(20)30028-8
pii: 100094
pmc: PMC7139106
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100094

Informations de copyright

© 2020 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL).

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest that pertain to this work. Please refer to the accompanying ICMJE disclosure forms for further details.

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Auteurs

Johannes Hartl (J)

First Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Rosa Miquel (R)

Institute of Liver Studies, King's College Hospital, London, United Kingdom.

Kalliopi Zachou (K)

Institute of Internal Medicine and Hepatology, Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece.

Guan-Wee Wong (GW)

Institute of Liver Studies, King's College Hospital, London, United Kingdom.

Asma Asghar (A)

Centre for Liver and Gastroenterology Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, United Kingdom.

Simon Pape (S)

Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, the Netherlands.
European Reference Network on Hepatological Diseases.

Marcial Sebode (M)

First Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Moritz Peiseler (M)

First Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Roman Zenouzi (R)

First Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Hanno Ehlken (H)

Department of Interdisciplinary Endoscopy, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Till Krech (T)

Department of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Christina Weiler-Normann (C)

First Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Martin Zeitz Centre for Rare Diseases, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Joost P H Drenth (JPH)

Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, the Netherlands.
European Reference Network on Hepatological Diseases.

Ye H Oo (YH)

Centre for Liver and Gastroenterology Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, United Kingdom.
Liver Transplant and Hepatobiliary Unit, University Hospital of Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Centre for Rare Diseases, Institute of Translational Medicine, University of Birmingham, Birmingham, United Kingdom.
European Reference Network on Hepatological Diseases.

George Nikolaos Dalekos (GN)

Institute of Internal Medicine and Hepatology, Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa, Greece.

Michael Heneghan (M)

Institute of Liver Studies, King's College Hospital, London, United Kingdom.

Christoph Schramm (C)

First Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Martin Zeitz Centre for Rare Diseases, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Ansgar Wilhelm Lohse (AW)

First Department of Internal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Martin Zeitz Centre for Rare Diseases, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
European Reference Network on Hepatological Diseases.

Classifications MeSH