The histopathology of congenital haemangioma and its clinical correlations: a long-term follow-up study of 55 cases.
Adolescent
Biopsy
Child
Child, Preschool
Congenital Abnormalities
/ diagnosis
Diagnosis, Differential
Female
Follow-Up Studies
Hemangioendothelioma
/ diagnosis
Hemangioma
/ diagnosis
Histocytochemistry
Humans
Immunohistochemistry
Infant
Infant, Newborn
Kasabach-Merritt Syndrome
/ diagnosis
Lymphatic Vessels
/ pathology
Male
Membrane Glycoproteins
/ metabolism
Neoplasms, Vascular Tissue
/ diagnosis
Sarcoma, Kaposi
/ diagnosis
Thrombocytopenia
/ pathology
congenital haemangioma
lymphatic vessels
non-involuting congenital haemangioma
partially involuting congenital haemangioma
podoplanin
rapidly involuting congenital haemangioma
thrombocytopenia
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
21
02
2020
revised:
02
04
2020
accepted:
04
04
2020
pubmed:
14
4
2020
medline:
20
8
2021
entrez:
14
4
2020
Statut:
ppublish
Résumé
Congenital haemangiomas (CHs) can be subdivided into different subtypes [rapidly involuting CHs (RICHs), non-involuting CHs (NICHs), and partially involuting CHs (PICHs)]. During the first few days of life, RICHs may be associated with transient but sometimes marked thrombocytopenia. We sought to assess the histological aspects and clinicopathological correlations of the three subtypes. We assessed the histopathological features of 10 RICHs, 25 NICHs, and 20 PICHs, described the patients' long-term clinical outcomes, and assessed clinicopathological correlations. All CHs were located in the dermis and hypodermis, and comprised both capillary lobules (with three distinct histopathological patterns) and extralobular large vessels. Most of the extralobular vessels were abnormal veins and abnormal lymphatic vessels. We did not observe significant correlations between the CH subtype, the histopathological pattern, and the time of the histopathological assessment. Interestingly, unexpected intralobular expression of podoplanin was found in neonatal biopsies of five RICHs and PICHs. Four of these five patients had concomitant thrombocytopenia. The podoplanin staining intensity decreased over time as the thrombocytopenia resolved and the tumour shrank. The histopathological features were similar in all three subtypes of CH, and were related to the time since disease onset; we consider that RICH, PICH and NICH form a single entity and differ only in their involuting potential. Along with the transient expression of intralobular podoplanin observed in some specimens from the newborn, the lobular architecture might lead to misdiagnosis of tufted haemangioma or kaposiform haemangioendothelioma.
Substances chimiques
Membrane Glycoproteins
0
PDPN protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
275-283Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
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