Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study.
amyloid
positron emission tomography imaging
preclinical and prodromal Alzheimer's disease
secondary prevention
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
26
08
2019
revised:
12
11
2019
accepted:
23
12
2019
pubmed:
14
4
2020
medline:
16
11
2021
entrez:
14
4
2020
Statut:
ppublish
Résumé
The Amyloid Imaging to Prevent Alzheimer's Disease (AMYPAD) Prognostic and Natural History Study (PNHS) aims at understanding the role of amyloid imaging in the earliest stages of Alzheimer's disease (AD). AMYPAD PNHS adds (semi-)quantitative amyloid PET imaging to several European parent cohorts (PCs) to predict AD-related progression as well as address methodological challenges in amyloid PET. AMYPAD PNHS is an open-label, prospective, multi-center, cohort study recruiting from multiple PCs. Around 2000 participants will undergo baseline amyloid positron emission tomography (PET), half of whom will be invited for a follow-up PET 12 at least 12 months later. Primary include several amyloid PET measurements (Centiloid, SUVr, BP Determining the role of amyloid PET for the understanding of this complex disease and potentially improving secondary prevention trials.
Identifiants
pubmed: 32281303
doi: 10.1002/alz.12069
pmc: PMC7984341
doi:
Substances chimiques
Amyloid
0
Biomarkers
0
Types de publication
Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
750-758Informations de copyright
© 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
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