Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na
Animals
Aorta
/ metabolism
Diet, Western
/ adverse effects
Elasticity
Epithelial Sodium Channels
/ deficiency
Female
Fibrosis
Mice, Inbred C57BL
Mice, Knockout
Nitric Oxide
/ metabolism
Nitric Oxide Synthase Type III
/ metabolism
Oxidative Stress
Renal Artery
/ pathology
Signal Transduction
Vascular Diseases
/ genetics
Vascular Remodeling
Vascular Stiffness
endothelial epithelial Na+ channel
endothelial nitric oxide synthase
oxidative stress
renal
Journal
American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990
Informations de publication
Date de publication:
01 05 2020
01 05 2020
Historique:
pubmed:
14
4
2020
medline:
15
7
2020
entrez:
14
4
2020
Statut:
ppublish
Résumé
Consumption of a Western diet (WD) induces central aortic stiffening that contributes to the transmittance of pulsatile blood flow to end organs, including the kidney. Our recent work supports that endothelial epithelial Na
Identifiants
pubmed: 32281419
doi: 10.1152/ajprenal.00517.2019
pmc: PMC7395479
doi:
Substances chimiques
Epithelial Sodium Channels
0
Scnn1a protein, mouse
0
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase Type III
EC 1.14.13.39
Nos3 protein, mouse
EC 1.14.13.39
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
F1220-F1228Subventions
Organisme : BLRD VA
ID : I01 BX001981
Pays : United States
Organisme : BLRD VA
ID : I01 BX003391
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL132012
Pays : United States
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