Elevated levels of D-dimer tested by immunoturbidimetry are associated with the extent of severity of pre-eclampsia.
D-dimer
Fibrin/fibrinogen degradation products
Immunology testing
Severe pre-eclampsia
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
22
08
2019
revised:
11
02
2020
accepted:
07
04
2020
pubmed:
14
4
2020
medline:
5
11
2020
entrez:
14
4
2020
Statut:
ppublish
Résumé
To establish the association between increased levels of D-dimer and severity of pre-eclampsia. A nested, prospective cohort, analytical case-control study was conducted among women with pre-eclampsia between March 2017 and March 2018. Inclusion criteria were age over 18 years, gestational age of more than 20 weeks, a single pregnancy with a living fetus, and a diagnosis of pre-eclampsia. D-dimer was measured by immunoturbidimetry at the time of diagnosis of pre-eclampsia, applying cut-off points adjusted for gestational age. Statistical analysis involved unconditional logistic regression for the association of elevated D-dimer with severe pre-eclampsia adjusted by confounding variables. There were 132 patients with pre-eclampsia, of which 44 were classed as controls and 88 were classed as having severe pre-eclampsia (case group). Cohort characteristics included: age between 18 and 45 years (mean 28.0 ± 6.3 years); presence of gestational hypertension (10.6%), chronic arterial hypertension (9.0%); and gestational diabetes (5.3%). In the case group, levels of D-dimer were significantly higher than in controls (19.3% vs 2.3%, odds ratio [OR] 10.30, 95% confidence interval [CI] 1.32-80.14, P=0.004) as well as significant in the unconditional logistic regression model adjusted for maternal age, parity, gestational age, and comorbidities (OR 10.02, 95% CI 1.28-78.68, P=0.028). Elevated levels of D-dimer and severe pre-eclampsia are strongly associated, reinforcing evidence that one of the physiopathologic bases of the condition is the activation of fibrinolysis and the coagulation system.
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
fibrin fragment D
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-247Subventions
Organisme : Hospital Universitario Mayor Méderi - Universidad del Rosario
Informations de copyright
© 2020 International Federation of Gynecology and Obstetrics.
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