A cut above (and below): Protein cleavage in the regulation of polycystin trafficking and signaling.
Cleavage
Polycystin
Processing
Signaling
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
28
02
2020
revised:
07
04
2020
accepted:
08
04
2020
pubmed:
14
4
2020
medline:
4
8
2021
entrez:
14
4
2020
Statut:
ppublish
Résumé
The polycystin-1 and 2 proteins, encoded by the genes mutated in Autosomal Dominant Polycystic Kidney Disease, are connected to a large number of biological pathways. While the nature of these connections and their relevance to the primary functions of the polycystin proteins have yet to be fully elucidated, it is clear that many of them are mediated by or depend upon cleavage of the polycystin-1 protein. Cleavage of polycystin-1 at its G protein coupled receptor proteolytic site is an obligate step in the protein's maturation and in aspects of its trafficking. This cleavage may also serve to prime polycystin-1 to play a role as a non-canonical G protein coupled receptor. Cleavage of the cytoplasmic polycystin-1C terminal tail releases fragments that are able to enter the nucleus and the mitochondria and to influence their activities. Understanding the nature of these cleavages, their regulation and their consequences is likely to provide valuable insights into both the physiological functions served by the polycystin proteins and the pathological consequences of their absence.
Identifiants
pubmed: 32283256
pii: S0898-6568(20)30111-X
doi: 10.1016/j.cellsig.2020.109634
pmc: PMC7269866
mid: NIHMS1584527
pii:
doi:
Substances chimiques
TRPP Cation Channels
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109634Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK072614
Pays : United States
Organisme : NIDDK NIH HHS
ID : RC2 DK120534
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007205
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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