Cellular mechanisms underlying carbon monoxide stimulated anion secretion in rat epididymal epithelium.

Animals Carbon Monoxide / metabolism Chloride Channels / metabolism Cystic Fibrosis Transmembrane Conductance Regulator / metabolism Epididymis / drug effects Epithelium / drug effects Heme Oxygenase (Decyclizing) / metabolism Ion Transport / drug effects Male Organometallic Compounds / pharmacology Rats, Sprague-Dawley
Anion secretion CFTR CO CaCC Epididymal epithelium

Journal

Nitric oxide : biology and chemistry
ISSN: 1089-8611
Titre abrégé: Nitric Oxide
Pays: United States
ID NLM: 9709307

Informations de publication

Date de publication:
01 08 2020
Historique:
received: 16 08 2019
revised: 13 03 2020
accepted: 06 04 2020
pubmed: 14 4 2020
medline: 16 12 2020
entrez: 14 4 2020
Statut: ppublish

Résumé

Epididymal epithelium possesses active ion transport properties conducive to the maintenance of appropriate epididymal intraluminal microenvironment. The endogenous gasotransmitter carbon monoxide (CO) regulates numerous cellular processes including water and electrolyte transport in various epithelia. However, the functional role of CO in epididymal epithelium is still elusive. This study aims to explore the potential regulatory effect of CO on transepithelial ion transport in rat epididymis. Using qPCR technique, we verified that endogenous CO synthase heme oxygenase 1 was expressed in rat caput, corpus, and cauda epididymis. In addition, endogenous CO was detected in rat cauda epididymis. Ussing chamber experiments showed that CORM-2, a CO donor, induced an increase of the short-circuit current (I

Identifiants

DOI: 10.1016/j.niox.2020.04.004 PMID: 32283263
pubmed: 32283263
pii: S1089-8603(19)30247-2
doi: 10.1016/j.niox.2020.04.004
pii:
doi:

Substances chimiques

CFTR protein, rat 0
Chloride Channels 0
Organometallic Compounds 0
tricarbonyldichlororuthenium (II) dimer 0
Cystic Fibrosis Transmembrane Conductance Regulator 126880-72-6
Carbon Monoxide 7U1EE4V452
Heme Oxygenase (Decyclizing) EC 1.14.14.18
Hmox1 protein, rat EC 1.14.14.18

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

30-37

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest None.

Auteurs

Lei Peng (L)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China.

Dong-Dong Gao (DD)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China.

Jia-Wen Xu (JW)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China.

Jian-Bang Xu (JB)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China.

Li-Jiao Ke (LJ)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China.

Zhuo-Er Qiu (ZE)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China.

Yun-Xin Zhu (YX)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China.

Yi-Lin Zhang (YL)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China. Electronic address: zhangylin9@mail.sysu.edu.cn.

Wen-Liang Zhou (WL)

School of Life Sciences, Sun Yat-sen University, 510006, No. 132, East Waihuan Road, Guangzhou Higher Education Mega Center, Guangzhou, China. Electronic address: lsszwl@mail.sysu.edu.cn.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Monoxyde de carbone › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux chlorure › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Transporteurs d'anions organiques ATP-dépendants › Protéines associées à la multirésistance aux médicaments › Protéine CFTR › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de l'homme › Épididyme › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Tissus › Épithélium › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Heme oxygenase (decyclizing) › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des ions › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Cellular mechanisms underlying carbon monoxide...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Cellular mechanisms underlying carbon monoxide...