Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy.
controlled release
corneal diseases
gene therapy
rAAV vectors
therapeutic contact lens
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
09 Apr 2020
09 Apr 2020
Historique:
received:
17
03
2020
revised:
03
04
2020
accepted:
07
04
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
15
4
2020
Statut:
epublish
Résumé
As an alternative to eye drops and ocular injections for gene therapy, the aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of viral vectors (recombinant adeno-associated virus, rAAV) to the eye in an effective way with improved patient compliance. Hydrogels of hydroxyethyl methacrylate (HEMA) with aminopropyl methacrylamide (APMA) (H
Identifiants
pubmed: 32283694
pii: pharmaceutics12040335
doi: 10.3390/pharmaceutics12040335
pmc: PMC7238179
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : SAF2017-83118-R
Organisme : Agencia Estatal de Investigación
ID : AEI
Organisme : Xunta de Galicia
ID : ED431C 2016/008
Organisme : European Regional Development Fund
ID : FEDER
Organisme : UDC-Inditex
ID : InTalent
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