Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market.
LC-MS/MS
herbs
oleandrin
plant toxins
urine
validation
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
09 04 2020
09 04 2020
Historique:
received:
06
03
2020
revised:
04
04
2020
accepted:
08
04
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
3
3
2021
Statut:
epublish
Résumé
Cardiac glycosides (CGs) are naturally occurring plant secondary metabolites that can be toxic to humans and animals. The aim of this work was to develop a targeted analytical method utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) for quantification of these plant toxins in a herbal-based food and human urine. The method included oleandrin, digoxin, digitoxin, convallatoxin, and ouabain. Samples of culinary herbs were extracted with acetonitrile and cleaned using Oasis
Identifiants
pubmed: 32283845
pii: toxins12040243
doi: 10.3390/toxins12040243
pmc: PMC7232191
pii:
doi:
Substances chimiques
Cardenolides
0
Cardiac Glycosides
0
Plant Preparations
0
oleandrin
II95UDU7I4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Belgian National Reference Laboratory for Mycotoxins, Plant toxins and Marine Biotoxins
ID : FAVV-NRL-GGO-TOX-2017, lot 2
Pays : International
Références
Eur J Pharmacol. 2014 Dec 5;744:18-27
pubmed: 25264938
Toxins (Basel). 2020 Mar 01;12(3):
pubmed: 32121600
Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Jan;35(1):118-133
pubmed: 28942718
Balkan Med J. 2016 Sep;33(5):559-562
pubmed: 27761287
Food Chem. 2018 Nov 15;266:514-523
pubmed: 30381220
Toxicon. 2019 Feb;158:63-68
pubmed: 30529380
Clin Pharmacokinet. 1977 Jan-Feb;2(1):1-16
pubmed: 322907
Fa Yi Xue Za Zhi. 2018 Jun;34(6):585-589
pubmed: 30896093
J Pharm Sci. 1977 Feb;66(2):242-53
pubmed: 839422
J Chromatogr A. 2020 May 10;1618:460903
pubmed: 32035664
J Vet Diagn Invest. 1996 Jul;8(3):358-64
pubmed: 8844581
J Am Coll Cardiol. 1985 May;5(5 Suppl A):10A-15A
pubmed: 2580874
Ann Cardiol Angeiol (Paris). 2012 Apr;61(2):128-31
pubmed: 21890104
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 15;975:65-76
pubmed: 25438245
Anal Bioanal Chem. 2011 Jan;399(3):1141-9
pubmed: 21076957
Drug Test Anal. 2015 Oct;7(10):937-46
pubmed: 25735870
J Chromatogr Sci. 2002 Oct;40(9):515-8
pubmed: 12433114
Ther Drug Monit. 2004 Dec;26(6):658-63
pubmed: 15570191
Am J Forensic Med Pathol. 2012 Mar;33(1):93-7
pubmed: 21926903
J Anal Toxicol. 2006 Nov-Dec;30(9):683-6
pubmed: 17137529
Annu Rev Med. 1975;26:159-71
pubmed: 1096754
Nihon Hoigaku Zasshi. 1997 Aug;51(4):315-8
pubmed: 9366138
J AOAC Int. 2003 Mar-Apr;86(2):412-31
pubmed: 12723926
Forensic Sci Int. 2008 Aug 6;179(2-3):e31-6
pubmed: 18602779
Anal Chem. 1999 Sep 15;71(18):4034-43
pubmed: 10500489
Clin Chim Acta. 2014 Apr 20;431:87-92
pubmed: 24508998
Int J Legal Med. 2008 Mar;122(2):109-14
pubmed: 17569072
J Am Coll Cardiol. 1985 May;5(5 Suppl A):43A-50A
pubmed: 3921586
Biol Pharm Bull. 2007 Sep;30(9):1653-6
pubmed: 17827715
Anal Sci. 2010;26(6):715-8
pubmed: 20543506
Crit Care Clin. 2012 Oct;28(4):527-35
pubmed: 22998989
Br Heart J. 1985 Sep;54(3):258-61
pubmed: 4041297