Role of miRNAs in prostate cancer: Do we really know everything?

Apoptosis Cell Proliferation Humans Male MicroRNAs / genetics Neoplasm Metastasis Prostatic Neoplasms / genetics
Apoptosis Carcinogenesis Metastasis MicroRNA Prostate cancer

Journal

Urologic oncology
ISSN: 1873-2496
Titre abrégé: Urol Oncol
Pays: United States
ID NLM: 9805460

Informations de publication

Date de publication:
07 2020
Historique:
received: 06 12 2019
revised: 12 03 2020
accepted: 14 03 2020
pubmed: 15 4 2020
medline: 2 4 2021
entrez: 15 4 2020
Statut: ppublish

Résumé

Many different genetic alterations, as well as complex epigenetic interactions, are the basis of the genesis and progression of prostate cancer (CaP). This is the reason why until now the molecular pathways related to development of this cancer were only partly known, and even less those that determine aggressive or indolent tumour behaviour. MicroRNAs (miRNAs) represent a class of about 22 nucleotides long, small non-coding RNAs, which are involved in gene expression regulation at the post-transcriptional level. MiRNAs play a crucial role in regulating several biological functions and preserving homeostasis, as they carry out a wide modulatory activity on various molecular signalling pathways. MiRNA genes are placed in cancer-related genomic regions or in fragile sites, and they have been proven to be involved in the main steps of carcinogenesis as oncogenes or oncosuppressors in many types of cancer, including CaP. We performed a narrative review to describe the relationship between miRNAs and the crucial steps of development and progression of CaP. The aims of this study were to improve the knowledge regarding the mechanisms underlying miRNA expression and their target genes, and to contribute to understanding the relationship between miRNA expression profiles and CaP.

Identifiants

DOI: 10.1016/j.urolonc.2020.03.007 PMID: 32284256
pubmed: 32284256
pii: S1078-1439(20)30091-0
doi: 10.1016/j.urolonc.2020.03.007
pii:
doi:

Substances chimiques

MicroRNAs 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

623-635

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Giovanni Cochetti (G)

Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

Jacopo Adolfo Rossi de Vermandois (JA)

Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

Vincenza Maulà (V)

Biotechnology Laboratory in Urology, Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

Matteo Giulietti (M)

Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona, Italy.

Monia Cecati (M)

Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona, Italy.

Michele Del Zingaro (M)

Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

Rosy Cagnani (R)

Biotechnology Laboratory in Urology, Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

Chiara Suvieri (C)

Biotechnology Laboratory in Urology, Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

Alessio Paladini (A)

Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy. Electronic address: alessiopaladini89@gmail.com.

Ettore Mearini (E)

Division of Urology Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Role of miRNAs in prostate cancer: Do we...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Role of miRNAs in prostate cancer: Do we...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role of miRNAs in prostate cancer: Do we...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Role of miRNAs in prostate cancer: Do we...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Role of miRNAs in prostate cancer: Do we...
questionsmedicales.fr › Maladies urogénitales › Tumeurs de l'appareil urogénital › Tumeurs de l'appareil génital mâle › Tumeurs de la prostate › Role of miRNAs in prostate cancer: Do we...