Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB.

AlkB Enzymes / chemistry AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase / chemistry AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase / chemistry DNA / chemistry DNA Repair DNA, Bacterial / chemistry DNA, Single-Stranded / chemistry Escherichia coli / enzymology Escherichia coli Proteins / chemistry Humans
ALKBH AlkA AlkB DNA adduct DNA damage DNA repair Escherichia coli (E. coli) adaptive response oxidative dealkylation pre-steady-state kinetics substrate specificity

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
22 05 2020
Historique:
received: 21 03 2020
revised: 10 04 2020
pubmed: 15 4 2020
medline: 29 12 2020
entrez: 15 4 2020
Statut: ppublish

Résumé

AlkB is a bacterial Fe(II)- and 2-oxoglutarate-dependent dioxygenase that repairs a wide range of alkylated nucleobases in DNA and RNA as part of the adaptive response to exogenous nucleic acid-alkylating agents. Although there has been longstanding interest in the structure and specificity of

Identifiants

DOI: 10.1074/jbc.RA120.013517 PMID: 32284330 PMC: PMC7247310
pubmed: 32284330
pii: S0021-9258(17)50265-3
doi: 10.1074/jbc.RA120.013517
pmc: PMC7247310
pii:
doi:

Substances chimiques

DNA, Bacterial 0
DNA, Single-Stranded 0
Escherichia coli Proteins 0
DNA 9007-49-2
ALKBH3 protein, human EC 1.14.11.-
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase EC 1.14.11.-
ALKBH2 protein, human EC 1.14.11.33
AlkB Enzymes EC 1.14.11.33
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase EC 1.14.11.33

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

7317-7326

Subventions

Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States

Informations de copyright

© 2020 Baldwin et al.

Références

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Auteurs

Michael R Baldwin (MR)

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.

Suzanne J Admiraal (SJ)

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600.

Patrick J O'Brien (PJ)

Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109-0600. Electronic address: pjobrien@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Dioxygenases › AlkB enzymes › AlkB Homolog 3, alpha-ketoglutarate-dependent dioxygenase › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN bactérien › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ADN simple brin › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › Transient kinetic analysis of oxidative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transient kinetic analysis of oxidative...