The molecular clock protein Bmal1 regulates cell differentiation in mouse embryonic stem cells.
ARNTL Transcription Factors
/ metabolism
Animals
CLOCK Proteins
/ genetics
Cell Differentiation
/ physiology
Circadian Clocks
/ physiology
Circadian Rhythm
/ genetics
Feedback, Physiological
/ physiology
Gene Expression
/ genetics
Induced Pluripotent Stem Cells
/ cytology
Mice
Mouse Embryonic Stem Cells
/ cytology
Period Circadian Proteins
/ metabolism
Pluripotent Stem Cells
/ cytology
Transcription, Genetic
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
25
08
2019
revised:
12
03
2020
accepted:
23
03
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
3
6
2021
Statut:
epublish
Résumé
Mammals optimize their physiology to the light-dark cycle by synchronization of the master circadian clock in the brain with peripheral clocks in the rest of the tissues of the body. Circadian oscillations rely on a negative feedback loop exerted by the molecular clock that is composed by transcriptional activators Bmal1 and Clock, and their negative regulators Period and Cryptochrome. Components of the molecular clock are expressed during early development, but onset of robust circadian oscillations is only detected later during embryogenesis. Here, we have used naïve pluripotent mouse embryonic stem cells (mESCs) to study the role of Bmal1 during early development. We found that, compared to wild-type cells,
Identifiants
pubmed: 32284355
pii: 3/5/e201900535
doi: 10.26508/lsa.201900535
pmc: PMC7156284
pii:
doi:
Substances chimiques
ARNTL Transcription Factors
0
Bmal1 protein, mouse
0
Period Circadian Proteins
0
CLOCK Proteins
EC 2.3.1.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2020 Gallardo et al.
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