Efficacy of Neuraminidase Inhibitors against H5N6 Highly Pathogenic Avian Influenza Virus in a Nonhuman Primate Model.

Animals Antiviral Agents / pharmacology Influenza A virus Influenza in Birds Influenza, Human / drug therapy Neuraminidase Phylogeny Primates
H5N6 NA inhibitor avian influenza viruses highly pathogenic nonhuman primate

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
23 06 2020
Historique:
received: 24 12 2019
accepted: 03 04 2020
pubmed: 15 4 2020
medline: 22 6 2021
entrez: 15 4 2020
Statut: epublish

Résumé

Attention has been paid to H5N6 highly pathogenic avian influenza virus (HPAIV) because of its heavy burden on the poultry industry and human mortality. Since an influenza A virus carrying N6 neuraminidase (NA) has never spread in humans, the potential for H5N6 HPAIV to cause disease in humans and the efficacy of antiviral drugs against the virus need to be urgently assessed. We used nonhuman primates to elucidate the pathogenesis of H5N6 HPAIV as well as to determine the efficacy of antiviral drugs against the virus. H5N6 HPAIV infection led to high fever in cynomolgus macaques. The lung injury caused by the virus was severe, with diffuse alveolar damage and neutrophil infiltration. In addition, an increase in interferon alpha (IFN-α) showed an inverse correlation with virus titers during the infection process. Oseltamivir was effective for reducing H5N6 HPAIV propagation, and continuous treatment with peramivir reduced virus propagation and the severity of symptoms in the early stage. This study also showed pathologically severe lung injury states in cynomolgus macaques infected with H5N6 HPAIV, even in those that received early antiviral drug treatments, indicating the need for close monitoring and further studies on virus pathogenicity and new antiviral therapies.

Identifiants

DOI: 10.1128/AAC.02561-19 PMID: 32284377 PMC: PMC7318037
pubmed: 32284377
pii: AAC.02561-19
doi: 10.1128/AAC.02561-19
pmc: PMC7318037
pii:
doi:

Substances chimiques

Antiviral Agents 0
Neuraminidase EC 3.2.1.18

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 American Society for Microbiology.

Références

Vet Microbiol. 2000 May 22;74(1-2):109-16
pubmed: 10799783
J Gen Virol. 2017 Jul;98(7):1573-1586
pubmed: 28721841
Nature. 2009 Jun 18;459(7249):931-9
pubmed: 19525932
Sci Rep. 2017 Nov 24;7(1):16280
pubmed: 29176564
Antivir Ther. 2018;23(5):435-441
pubmed: 29372885
Curr Top Microbiol Immunol. 2014;385:185-204
pubmed: 25048543
Nat Med. 2012 Jan 15;18(2):260-6
pubmed: 22245779
MMWR Recomm Rep. 2011 Jan 21;60(1):1-24
pubmed: 21248682
Expert Rev Anti Infect Ther. 2014 Feb;12(2):165-9
pubmed: 24350808
Eur Respir J. 2017 Mar 8;49(3):
pubmed: 28275173
JAMA. 1970 Feb 16;211(7):1149-56
pubmed: 4904254
Acta Physiol (Oxf). 2016 Jan;216(1):42-89
pubmed: 25728499
Antimicrob Agents Chemother. 2014 Aug;58(8):4795-803
pubmed: 24913156
Emerg Infect Dis. 2017 Apr;23(4):691-695
pubmed: 28322695
Antimicrob Agents Chemother. 2015 Aug;59(8):4962-73
pubmed: 26055368
Clin Microbiol Infect. 2016 Jun;22(6):574.e1-5
pubmed: 27040806
J Virol. 2009 Jun;83(11):5825-34
pubmed: 19297490
PLoS One. 2015 Mar 13;10(3):e0119115
pubmed: 25768797
Microbiol Immunol. 2017 Sep;61(9):387-397
pubmed: 28815716
J Exp Med. 2007 Apr 16;204(4):723-34
pubmed: 17371929
N Engl J Med. 2015 Jul 30;373(5):487-9
pubmed: 26222578
Jpn J Infect Dis. 2008 Mar;61(2):157-60
pubmed: 18362412
Nat Med. 2006 Oct;12(10):1203-7
pubmed: 16964257
PLoS One. 2013 Sep 23;8(9):e75910
pubmed: 24086663
PLoS One. 2012;7(5):e37220
pubmed: 22623997
Infect Drug Resist. 2017 Apr 20;10:121-134
pubmed: 28458567
J Antimicrob Chemother. 2016 Nov;71(11):3036-3045
pubmed: 27432605
Am J Pathol. 2010 Jul;177(1):166-75
pubmed: 20508031
Antivir Ther. 2010;15(5):721-6
pubmed: 20710053
J Clin Pathol. 2015 Jan;68(1):57-63
pubmed: 25378539
J Virol. 2016 Jun 24;90(14):6235-6243
pubmed: 27122581
J Virol. 2017 Dec 14;92(1):
pubmed: 29046464
Virology. 2010 Nov 25;407(2):178-84
pubmed: 20822788
Clin Infect Dis. 2019 Mar 19;68(7):1100-1109
pubmed: 30124826
mSphere. 2018 Jan 3;3(1):
pubmed: 29299528
Clin Infect Dis. 2014 Dec 15;59(12):e172-85
pubmed: 25115871
Clin Infect Dis. 2017 Aug 1;65(3):383-388
pubmed: 28407105
J Gen Virol. 2007 Apr;88(Pt 4):1266-74
pubmed: 17374771
Curr Pharm Des. 2017;23(18):2616-2622
pubmed: 28302021

Auteurs

Cong Thanh Nguyen (CT)

Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
ORCID: 0000-0002-5973-6210

Saori Suzuki (S)

Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.

Yasushi Itoh (Y)

Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan yasushii@belle.shiga-med.ac.jp.

Hirohito Ishigaki (H)

Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.

Misako Nakayama (M)

Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.

Kaori Hayashi (K)

Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
Department of Gynecology, Shiga University of Medical Science, Otsu, Japan.

Keita Matsuno (K)

Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.
ORCID: 0000-0002-4205-6526

Masatoshi Okamatsu (M)

Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Yoshihiro Sakoda (Y)

Laboratory of Microbiology, Department of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education, Hokkaido University, Sapporo, Japan.

Hiroshi Kida (H)

Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.

Kazumasa Ogasawara (K)

Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan.
Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Efficacy of Neuraminidase Inhibitors against...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Efficacy of Neuraminidase Inhibitors against...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Efficacy of Neuraminidase Inhibitors against...
questionsmedicales.fr › Maladies de l'animal › Maladies des oiseaux › Grippe chez les oiseaux › Efficacy of Neuraminidase Inhibitors against...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › Efficacy of Neuraminidase Inhibitors against...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Sialidase › Efficacy of Neuraminidase Inhibitors against...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › Efficacy of Neuraminidase Inhibitors against...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Efficacy of Neuraminidase Inhibitors against...