Assessing the Activity of Multidrug Resistance-Associated Protein 1 at the Lung Epithelial Barrier.
6-bromo-7-11C-methylpurine
PET
lung epithelial barrier
multidrug resistance–associated protein 1
pulmonary drug disposition
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
24
02
2020
accepted:
19
03
2020
pubmed:
15
4
2020
medline:
10
3
2021
entrez:
15
4
2020
Statut:
ppublish
Résumé
Multidrug resistance-associated protein 1 (adenosine triphosphate-binding cassette subfamily C member 1 [ABCC1]) is abundantly expressed at the lung epithelial barrier, where it may influence the pulmonary disposition of inhaled drugs and contribute to variability in therapeutic response. The aim of this study was to assess the impact of ABCC1 on the pulmonary disposition of 6-bromo-7-
Identifiants
pubmed: 32284394
pii: jnumed.120.244038
doi: 10.2967/jnumed.120.244038
doi:
Substances chimiques
6-bromo-7-methylpurine
0
Carbon Radioisotopes
0
Multidrug Resistance-Associated Proteins
0
Propionates
0
Purines
0
Quinolines
0
verlukast
5Q9O54P0H7
multidrug resistance-associated protein 1
Y49M64GZ4Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1650-1657Informations de copyright
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.