Intraoperative Dexmedetomidine Versus Midazolam in Patients Undergoing Peripheral Surgery With Mild Traumatic Brain Injuries: A Retrospective Cohort Analysis.
analgesia
anesthesia
dexmedetomidine
inflammatory response
midazolam
sedation
Journal
Dose-response : a publication of International Hormesis Society
ISSN: 1559-3258
Titre abrégé: Dose Response
Pays: United States
ID NLM: 101308899
Informations de publication
Date de publication:
Historique:
received:
09
08
2019
revised:
23
02
2020
accepted:
25
02
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
15
4
2020
Statut:
epublish
Résumé
The intra- and postoperative effects of dexmedetomidine are not completely consistent and midazolam/fentanyl is most widely used in peripheral surgeries. The objectives of the study were to evaluate the sedative, analgesic, hemodynamic, anti-inflammatory, and antioxidant effects of dexmedetomidine against midazolam in patients undergoing peripheral surgeries with mild traumatic brain injuries. Medical records of patients who underwent peripheral surgeries with mild traumatic brain injury were included in the analysis. Patients received intraoperative midazolam (MDZ cohort, n = 225) or dexmedetomidine (DEX cohort, n = 231). Pre-, intra-, and postoperative characteristics of patients were collected and analyzed. After administration of anesthesia, up to 40 minutes, patients of the MDZ group had lower modified observer's assessment of alertness/sedation score than those of the DEX group ( Intraoperative DEX offers better sedation, postoperative analgesia, and clinical recovery for peripheral surgeries and suppresses inflammatory response. III.
Sections du résumé
BACKGROUND
BACKGROUND
The intra- and postoperative effects of dexmedetomidine are not completely consistent and midazolam/fentanyl is most widely used in peripheral surgeries. The objectives of the study were to evaluate the sedative, analgesic, hemodynamic, anti-inflammatory, and antioxidant effects of dexmedetomidine against midazolam in patients undergoing peripheral surgeries with mild traumatic brain injuries.
METHODS
METHODS
Medical records of patients who underwent peripheral surgeries with mild traumatic brain injury were included in the analysis. Patients received intraoperative midazolam (MDZ cohort, n = 225) or dexmedetomidine (DEX cohort, n = 231). Pre-, intra-, and postoperative characteristics of patients were collected and analyzed.
RESULTS
RESULTS
After administration of anesthesia, up to 40 minutes, patients of the MDZ group had lower modified observer's assessment of alertness/sedation score than those of the DEX group (
CONCLUSIONS
CONCLUSIONS
Intraoperative DEX offers better sedation, postoperative analgesia, and clinical recovery for peripheral surgeries and suppresses inflammatory response.
LEVEL OF EVIDENCE
METHODS
III.
Identifiants
pubmed: 32284701
doi: 10.1177/1559325820916342
pii: 10.1177_1559325820916342
pmc: PMC7139181
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1559325820916342Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
J Intensive Care Med. 2015 Mar;30(3):167-75
pubmed: 24227448
Clin Neurol Neurosurg. 2016 Jul;146:105-8
pubmed: 27206212
J Clin Med. 2015 May 20;4(5):1051-62
pubmed: 26239465
J Res Med Sci. 2011 Sep;16(9):1139-48
pubmed: 22973382
Anesth Analg. 2006 Jul;103(1):63-7, table of contents
pubmed: 16790627
Ann N Y Acad Sci. 2010 Oct;1207:143-8
pubmed: 20955437
Med Sci Monit. 2016 Oct 04;22:3544-3551
pubmed: 27701366
Anesth Analg. 2010 Jan 1;110(1):47-56
pubmed: 19713256
Reg Anesth Pain Med. 2019 Mar;44(3):319-324
pubmed: 30777901
Br J Anaesth. 2015 Oct;115(4):569-77
pubmed: 26385665
PLoS One. 2017 Jan 20;12(1):e0169525
pubmed: 28107373
Anesthesiology. 2009 Feb;110(2):231-8
pubmed: 19194149
Eurasian J Med. 2010 Aug;42(2):61-5
pubmed: 25610125
Oxid Med Cell Longev. 2015;2015:186736
pubmed: 26171113
Medicine (Baltimore). 2018 Sep;97(39):e12565
pubmed: 30278560
Mayo Clin Proc. 2017 Jul;92(7):1042-1052
pubmed: 28601422
Anesth Prog. 2015 Spring;62(1):31-9
pubmed: 25849473
J Clin Anesth. 2017 Aug;40:25-32
pubmed: 28625441
Mol Med Rep. 2017 Jan;15(1):169-179
pubmed: 27959401
Ann Surg. 2011 Apr;253(4):798-810
pubmed: 21475023