Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
27
04
2019
accepted:
09
01
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
16
12
2020
Statut:
epublish
Résumé
For decades, numerous studies have proposed that fast muscles contribute to quick movement, while slow muscles underlie locomotion requiring endurance. By generating mutant zebrafish whose fast muscles are synaptically silenced, we examined the contribution of fast muscles in both larval and adult zebrafish. In the larval stage, mutants lacked the characteristic startle response to tactile stimuli: bending of the trunk (C-bend) followed by robust forward propulsion. Unexpectedly, adult mutants with silenced fast muscles showed robust C-bends and forward propulsion upon stimulation. Retrograde labeling revealed that motor neurons genetically programmed to form synapses on fast muscles are instead rerouted and innervate slow muscles, which led to partial conversion of slow and intermediate muscles to fast muscles. Thus, extended silencing of fast muscle synapses changed motor neuron innervation and caused muscle cell type conversion, revealing an unexpected mechanism of locomotory adaptation.
Identifiants
pubmed: 32284992
doi: 10.1126/sciadv.aax8382
pii: aax8382
pmc: PMC7141830
doi:
Substances chimiques
Receptors, Nicotinic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaax8382Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Références
Nat Biotechnol. 2013 Mar;31(3):227-9
pubmed: 23360964
J Neurosci. 2014 Jul 30;34(31):10211-8
pubmed: 25080583
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17711-6
pubmed: 23045675
J Neurosci. 2013 Jun 26;33(26):10875-86
pubmed: 23804107
J Physiol Sci. 2015 May;65(3):217-21
pubmed: 25782439
J Neurosci. 2001 Aug 1;21(15):5439-48
pubmed: 11466415
J Neurogenet. 2016 Jun;30(2):89-100
pubmed: 27302612
Sci Adv. 2019 Jan 02;5(1):eaau2956
pubmed: 30613770
Physiol Rev. 2011 Oct;91(4):1447-531
pubmed: 22013216
Nat Genet. 2004 Jan;36(1):88-93
pubmed: 14702044
Prog Brain Res. 1993;98:121-7
pubmed: 8248499
Exp Neurol. 2009 Sep;219(1):258-65
pubmed: 19500575
Development. 2007 Aug;134(15):2771-81
pubmed: 17596281
Curr Biol. 2013 Feb 18;23(4):307-11
pubmed: 23375894
Acta Histochem. 1993 Sep;95(1):31-44
pubmed: 8279233
J Neurosci. 2014 Oct 15;34(42):14046-54
pubmed: 25319701
Development. 1996 Nov;122(11):3371-80
pubmed: 8951054
J Neurosci. 1993 Oct;13(10):4101-13
pubmed: 8410180
J Exp Biol. 2000 Sep;203(Pt 17):2565-79
pubmed: 10934000
Dev Growth Differ. 2007 Jan;49(1):1-11
pubmed: 17227340
J Gen Physiol. 2011 Sep;138(3):353-66
pubmed: 21844221
Development. 2008 Jun;135(12):2115-26
pubmed: 18480160
J Neurophysiol. 2004 Nov;92(5):2898-908
pubmed: 15212431
Nature. 2002 Aug 15;418(6899):797-801
pubmed: 12181572
Nature. 2003 Jul 24;424(6947):430-4
pubmed: 12879071
J Exp Biol. 2012 Jun 1;215(Pt 11):1854-62
pubmed: 22573764
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13286-91
pubmed: 8917583
Histochemistry. 1986;84(3):251-5
pubmed: 2940205
Cell Biosci. 2015 Nov 14;5:62
pubmed: 26568818
Chem Phys Lipids. 2006 Sep;143(1-2):11-21
pubmed: 16797513
Nature. 1986 May 22-28;321(6068):406-11
pubmed: 2423878
Sci Rep. 2017 May 10;7(1):1674
pubmed: 28490756
J Neurosci. 2012 Aug 8;32(32):10925-39
pubmed: 22875927
PLoS One. 2014 Mar 11;9(3):e90245
pubmed: 24618564
J Exp Biol. 2007 Jul;210(Pt 14):2526-39
pubmed: 17601957
Dev Biol. 2011 Jul 15;355(2):194-204
pubmed: 21554867
Nat Cell Biol. 2002 Jan;4(1):83-8
pubmed: 11744924
PLoS Biol. 2004 Oct;2(10):e294
pubmed: 15328533
Curr Biol. 2015 Oct 19;25(20):2610-20
pubmed: 26412127
Nat Commun. 2019 May 22;10(1):2268
pubmed: 31118414
Physiol Rev. 1970 Jan;50(1):40-62
pubmed: 4904270
Histochem J. 1979 Mar;11(2):127-36
pubmed: 155667
Dev Neurobiol. 2016 Aug;76(8):916-36
pubmed: 26585318
Nature. 1988 Oct 27;335(6193):824-7
pubmed: 3185712
Anat Embryol (Berl). 1983;167(1):125-39
pubmed: 6881540
Anat Embryol (Berl). 1990;182(1):93-102
pubmed: 2240597