Genetic and environmental factors of schizophrenia and autism spectrum disorder: insights from twin studies.
Autism spectrum disorder
Epigenetics
Psychiatric disorders
Schizophrenia
Twin study
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
30
01
2020
accepted:
05
04
2020
pubmed:
15
4
2020
medline:
16
10
2021
entrez:
15
4
2020
Statut:
ppublish
Résumé
Twin studies of psychiatric disorders such as schizophrenia and autism spectrum disorder have employed epidemiological approaches that determine heritability by comparing the concordance rate between monozygotic twins (MZs) and dizygotic twins. The basis for these studies is that MZs share 100% of their genetic information. Recently, biological studies based on molecular methods are now being increasingly applied to examine the differences between MZs discordance for psychiatric disorders to unravel their possible causes. Although recent advances in next-generation sequencing have increased the accuracy of this line of research, there has been greater emphasis placed on epigenetic changes versus DNA sequence changes as the probable cause of discordant psychiatric disorders in MZs. Since the epigenetic status differs in each tissue type, in addition to the DNA from the peripheral blood, studies using DNA from nerve cells induced from postmortem brains or induced pluripotent stem cells are being carried out. Although it was originally thought that epigenetic changes occurred as a result of environmental factors, and thus were not transmittable, it is now known that such changes might possibly be transmitted between generations. Therefore, the potential possible effects of intestinal flora inside the body are currently being investigated as a cause of discordance in MZs. As a result, twin studies of psychiatric disorders are greatly contributing to the elucidation of genetic and environmental factors in the etiology of psychiatric conditions.
Identifiants
pubmed: 32285255
doi: 10.1007/s00702-020-02188-w
pii: 10.1007/s00702-020-02188-w
pmc: PMC7578126
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1501-1515Références
J Psychiatry Neurosci. 2017 Mar;42(2):122-130
pubmed: 28245176
Psychiatry. 1948 Aug;11(3):263-73
pubmed: 18889231
Acta Psychiatr Scand. 1991 May;83(5):395-401
pubmed: 1853734
J Child Psychol Psychiatry. 1996 Oct;37(7):785-801
pubmed: 8923222
JAMA Psychiatry. 2015 Jul;72(7):651-8
pubmed: 25945901
Neurosci Biobehav Rev. 2020 Feb;109:103-113
pubmed: 31843545
Twin Res Hum Genet. 2014 Apr;17(2):108-20
pubmed: 24556202
Mol Neurobiol. 2017 Aug;54(6):4343-4352
pubmed: 27343181
Clin Transl Med. 2017 Nov 28;6(1):43
pubmed: 29181591
Schizophr Res. 2013 May;146(1-3):289-90
pubmed: 23507357
Genomics. 1999 Oct 15;61(2):133-44
pubmed: 10534399
J Psychiatr Res. 2014 Jul;54:100-8
pubmed: 24726638
Mol Psychiatry. 2012 Dec;17(12):1194-205
pubmed: 22290124
Epigenomics. 2015 Aug;7(5):781-90
pubmed: 26344807
Hum Mol Genet. 2011 Dec 15;20(24):4786-96
pubmed: 21908516
Front Neurosci. 2019 Jul 17;13:712
pubmed: 31379474
J Autism Dev Disord. 2017 Feb;47(2):480-489
pubmed: 27882443
J Child Psychol Psychiatry. 2016 Mar;57(3):271-92
pubmed: 26782158
Psychiatr Genet. 1996 Spring;6(1):1-5
pubmed: 8925251
Nat Rev Neurosci. 2017 Oct;18(10):573-584
pubmed: 28878372
J Genet Genomics. 2017 Jun 20;44(6):295-306
pubmed: 28645778
Twin Res Hum Genet. 2010 Oct;13(5):455-60
pubmed: 20874467
J Med Genet. 2003 Feb;40(2):E16
pubmed: 12566534
Mol Cells. 2019 Sep 30;42(9):617-627
pubmed: 31564073
Glia. 2018 Jan;66(1):78-93
pubmed: 28925578
Psychiatry Res. 2012 Aug 15;198(3):533-7
pubmed: 23102571
Schizophr Res. 2010 Jul;120(1-3):150-8
pubmed: 20580881
Am J Med Genet. 1989 Jan;32(1):19-21
pubmed: 2705478
Schizophr Bull. 1992;18(2):159-70
pubmed: 1621064
Hum Genet. 1998 Jul;103(1):41-7
pubmed: 9737774
FASEB J. 2010 Aug;24(8):3036-51
pubmed: 20375269
Eur Arch Psychiatry Clin Neurosci. 2017 Aug;267(5):391-402
pubmed: 28039552
Cell Stem Cell. 2017 Aug 3;21(2):195-208.e6
pubmed: 28736215
Nature. 1977 Feb 24;265(5596):726-8
pubmed: 558516
Am J Hum Genet. 1994 Mar;54(3):437-42
pubmed: 8116613
Front Hum Neurosci. 2017 Jun 22;11:322
pubmed: 28690503
Curr Top Microbiol Immunol. 2006;310:81-115
pubmed: 16909908
Arch Gen Psychiatry. 1987 Jul;44(7):634-41
pubmed: 3606329
Proc Natl Acad Sci U S A. 2006 May 9;103(19):7482-7
pubmed: 16641098
NPJ Schizophr. 2018 Apr 13;4(1):7
pubmed: 29654278
BMC Genomics. 2006 May 18;7:118
pubmed: 16709250
Am J Psychiatry. 2017 Apr 1;174(4):319-328
pubmed: 27838934
Nat Med. 2016 Nov;22(11):1220-1228
pubmed: 27783065
Neuromolecular Med. 2013 Mar;15(1):95-101
pubmed: 22961555
Hist Psychiatry. 2014 Dec;25(4):431-40
pubmed: 25395441
Adv Exp Med Biol. 2019;1121:7-20
pubmed: 31392648
Clin Genet. 2013 Jul;84(1):31-6
pubmed: 23061379
PLoS One. 2011 Mar 02;6(3):e17125
pubmed: 21399695
Hum Genome Var. 2017 Jul 27;4:17032
pubmed: 28765789
Arch Gen Psychiatry. 2011 Nov;68(11):1095-102
pubmed: 21727249
Mol Psychiatry. 2014 Apr;19(4):495-503
pubmed: 23608919
Hum Mol Genet. 2002 May 15;11(11):1317-25
pubmed: 12019213
Case Rep Genet. 2014;2014:516529
pubmed: 24563798
Cell. 2015 Jul 16;162(2):375-390
pubmed: 26186191
Schizophr Res. 2017 Mar;181:75-82
pubmed: 28277309
PLoS One. 2013 Jun 21;8(6):e66729
pubmed: 23805272
Hum Genet. 2017 Feb;136(2):263-274
pubmed: 28035465
Science. 2018 Feb 9;359(6376):693-697
pubmed: 29439242
Chin Med J (Engl). 2016 Mar 20;129(6):690-5
pubmed: 26960372
Mol Ther Nucleic Acids. 2019 Mar 1;14:204-211
pubmed: 30623854
Schizophr Bull. 1994;20(3):423-32
pubmed: 7526445
BMC Med Genet. 2008 Dec 22;9:115
pubmed: 19102774
Int J Neuropsychopharmacol. 2007 Aug;10(4):565-73
pubmed: 17291370
Am J Psychiatry. 1998 Mar;155(3):422-4
pubmed: 9501757
Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):557-64
pubmed: 18081029
J Autism Child Schizophr. 1971 Jan-Mar;1(1):20-32
pubmed: 4947755
NPJ Schizophr. 2018 Nov 19;4(1):23
pubmed: 30451850
Biol Psychiatry. 2018 Mar 15;83(6):492-498
pubmed: 28987712
Hum Genet. 1982;62(4):364-7
pubmed: 6891940
Cells. 2019 Nov 23;8(12):
pubmed: 31771166
Science. 2017 Jul 14;357(6347):212-216
pubmed: 28706074
Schizophr Res. 2019 Feb;204:183-192
pubmed: 30121189
Clin Dev Immunol. 2013;2013:608654
pubmed: 23690824
Lancet. 2013 Apr 20;381(9875):1371-1379
pubmed: 23453885
JAMA. 2017 Sep 26;318(12):1182-1184
pubmed: 28973605
Am J Psychiatry. 2018 Apr 1;175(4):316-326
pubmed: 29241358
Transl Psychiatry. 2014 Sep 02;4:e435
pubmed: 25180574
BMJ. 1996 Feb 10;312(7027):327-8
pubmed: 8611819
Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1;120B(1):1-10
pubmed: 12815731
Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):37-42
pubmed: 15635661
Nat Genet. 2003 Oct;35(2):171-5
pubmed: 12949534
Dev Neurobiol. 2012 Oct;72(10):1277-87
pubmed: 22753382
Arch Gen Psychiatry. 2012 Apr;69(4):349-59
pubmed: 22474104
Genome Med. 2010 Apr 07;2(4):23
pubmed: 20374639
Front Hum Neurosci. 2009 Oct 26;3:35
pubmed: 19893757
J Med Genet. 2017 Aug;54(8):511-520
pubmed: 28314733
World J Gastroenterol. 2016 Jan 7;22(1):361-8
pubmed: 26755882
Epigenetics. 2015;10(11):1014-23
pubmed: 26479702
Mol Autism. 2015 Jul 22;6:44
pubmed: 26199714
Semin Fetal Neonatal Med. 2017 Dec;22(6):367-375
pubmed: 29122542
Clin Epigenetics. 2019 May 9;11(1):73
pubmed: 31072398
BMC Med Genomics. 2015 May 06;8:17
pubmed: 25943100
Arch Gen Psychiatry. 2005 Nov;62(11):1205-13
pubmed: 16275808
Psychiatry Res. 1993 Jul;48(1):27-36
pubmed: 8416016
Hum Genet. 1981;59(1):39-46
pubmed: 10819020
Schizophr Res. 2015 Dec;169(1-3):433-440
pubmed: 26441003