Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.

Aging / metabolism Animals Brain / metabolism Drosophila Drosophila Proteins / metabolism Endosomes / metabolism Lysosomes / metabolism Synaptic Transmission / physiology Vesicular Transport Proteins / metabolism
D. melanogaster Drosophila Rab7 TBC1D5 VPS29 VPS35 cell biology endolysosomal trafficking neuroscience

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
14 04 2020
Historique:
received: 18 09 2019
accepted: 11 04 2020
pubmed: 15 4 2020
medline: 30 3 2021
entrez: 15 4 2020
Statut: epublish

Résumé

Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson's and Alzheimer's disease, our understanding of retromer function in the adult brain remains limited, in part because

Identifiants

DOI: 10.7554/eLife.51977 PMID: 32286230 PMC: PMC7182434
pubmed: 32286230
doi: 10.7554/eLife.51977
pii: 51977
pmc: PMC7182434
doi:
pii:

Substances chimiques

Drosophila Proteins 0
Vesicular Transport Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIA NIH HHS
ID : U01 AG046161
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA125123
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083092
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053960
Pays : United States
Organisme : NIA NIH HHS
ID : U54 AG065187
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103967
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG061357
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103555
Pays : United States
Organisme : Alzheimer's Association
ID : AARFD-16-442630
Pays : United States

Informations de copyright

© 2020, Ye et al.

Déclaration de conflit d'intérêts

HY, SO, DL, ZZ, LW, YL, JG, UT, AR, JS No competing interests declared, HB Reviewing editor, eLife

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Auteurs

Hui Ye (H)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Department of Neurology, Baylor College of Medicine, Houston, United States.
ORCID: 0000-0003-3965-9702

Shamsideen A Ojelade (SA)

Department of Neurology, Baylor College of Medicine, Houston, United States.

David Li-Kroeger (D)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
ORCID: 0000-0001-6473-7691

Zhongyuan Zuo (Z)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.

Liping Wang (L)

Program in Developmental Biology, Baylor College of Medicine, Houston, United States.

Yarong Li (Y)

Department of Neurology, Baylor College of Medicine, Houston, United States.

Jessica Yj Gu (JY)

Department of Cell and Systems Biology, University of Toronto, Ontario, Canada.

Ulrich Tepass (U)

Department of Cell and Systems Biology, University of Toronto, Ontario, Canada.

Avital Adah Rodal (AA)

Department of Biology, Brandeis University, Waltham, United States.
ORCID: 0000-0002-2051-8304

Hugo J Bellen (HJ)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
Department of Neuroscience, Baylor College of Medicine, Houston, United States.
Howard Hughes Medical Institute, Houston, United States.
Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.
ORCID: 0000-0001-5992-5989

Joshua M Shulman (JM)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States.
Department of Neurology, Baylor College of Medicine, Houston, United States.
Program in Developmental Biology, Baylor College of Medicine, Houston, United States.
Department of Neuroscience, Baylor College of Medicine, Houston, United States.
Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States.
ORCID: 0000-0002-1835-1971

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Eucaryotes › Animaux › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Retromer subunit, VPS29, regulates synaptic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Retromer subunit, VPS29, regulates synaptic...