Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida.
Animals
Apoptosis
Avian Proteins
/ genetics
Chickens
HMGB1 Protein
/ genetics
Inflammation
Interleukin-6
/ genetics
Lung
/ metabolism
Matrix Metalloproteinases
/ genetics
Pasteurella Infections
/ metabolism
Pasteurella multocida
/ pathogenicity
Poultry Diseases
/ metabolism
Receptor-Interacting Protein Serine-Threonine Kinases
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 04 2020
14 04 2020
Historique:
received:
14
09
2018
accepted:
05
03
2020
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
25
11
2020
Statut:
epublish
Résumé
Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Therefore, P. multocida Q (a reference standard strain isolated from chicken) and 1G1 (a clinic isolated strain from duck) were selected to infect chickens, establishing fowl cholera-induced laying hen models. Several important proteins involved in the process of lung injury were identified and quantified using immunohistochemistry and WB. The results showed that chicken lungs infected with bacteria for 24 h showed congestion and edema. The inflammatory factors HMGB1 and IL-6, intercellular matrix MMP, the cell apoptosis-associated caspase-3 and necrotic apoptosis signal molecules RIPK1 and RIPK3 were widely expressed in the lungs of group Q and were significantly different compared with those of 1G1 group and uninfected group (P < 0.05). The results indicated that RIPK1 and RIPK3 are involved in the injury process of chicken lungs after infection with P. multocida, and the mechanisms of lung injury induced by different strains are different.
Identifiants
pubmed: 32286320
doi: 10.1038/s41598-020-62042-7
pii: 10.1038/s41598-020-62042-7
pmc: PMC7156477
doi:
Substances chimiques
Avian Proteins
0
HMGB1 Protein
0
Interleukin-6
0
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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