Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery.
Autophagy
BNIP3L/NIX
dimerization
mitophagy
selective autophagy
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
pubmed:
15
4
2020
medline:
15
12
2021
entrez:
15
4
2020
Statut:
ppublish
Résumé
Mitophagy is a conserved intracellular catabolic process responsible for the selective removal of dysfunctional or superfluous mitochondria to maintain mitochondrial quality and need in cells. Here, we examine the mechanisms of receptor-mediated mitophagy activation, with the focus on BNIP3L/NIX mitophagy receptor, proven to be indispensable for selective removal of mitochondria during the terminal differentiation of reticulocytes. The molecular mechanisms of selecting damaged mitochondria from healthy ones are still very obscure. We investigated BNIP3L dimerization as a potentially novel molecular mechanism underlying BNIP3L-dependent mitophagy. Forming stable homodimers, BNIP3L recruits autophagosomes more robustly than its monomeric form. Amino acid substitutions of key transmembrane residues of BNIP3L, BNIP3L
Identifiants
pubmed: 32286918
doi: 10.1080/15548627.2020.1755120
pmc: PMC8143235
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
BNIP3L protein, human
0
Membrane Proteins
0
Proto-Oncogene Proteins
0
Tumor Suppressor Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1232-1243Références
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