Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders.
Alzheimer's disease
Amyotrophic lateral sclerosis
Astrocyte-derived extracellular vesicles
Astrocytes
Exosomes
Microvesicles
Neuroinflammation
Neurological disorders
Parkinson's disease
Stroke
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
10 07 2020
10 07 2020
Historique:
received:
11
02
2020
revised:
08
04
2020
accepted:
09
04
2020
pubmed:
15
4
2020
medline:
22
6
2021
entrez:
15
4
2020
Statut:
ppublish
Résumé
Extracellular vesicles (EVs) released by neural cells play an essential role in brain homeostasis and the crosstalk between neural cells and the periphery. EVs are diverse, nano-sized vesicles, which transport proteins, nucleic acids, and lipids between cells over short and long expanses and hence are proficient for modulating the target cells. EVs released from neural cells are implicated in synaptic plasticity, neuron-glia interface, neuroprotection, neuroregeneration, and the dissemination of neuropathological molecules. This review confers the various properties of EVs secreted by astrocytes and their potential role in health and disease with a focus on evolving concepts. Naïve astrocytes shed EVs containing a host of neuroprotective compounds, which include fibroblast growth factor-2, vascular endothelial growth factor, and apolipoprotein-D. Stimulated astrocytes secrete EVs with neuroprotective molecules including heat shock proteins, synapsin 1, unique microRNAs, and glutamate transporters. Well-characterized astrocyte-derived EVs (ADEVs) generated in specific culture conditions and ADEVs that are engineered to carry the desired miRNAs or proteins are likely useful for treating brain injury and neurogenerative diseases. On the other hand, in conditions such as Alzheimer's disease (AD), stroke, Parkinson's disease, Amyotrophic lateral sclerosis (ALS), and other neuroinflammatory conditions, EVs released by activated astrocytes appear to mediate or exacerbate the pathological processes. The examples include ADEVs spreading the dysregulated complement system in AD, mediating motoneuron toxicity in ALS, and stimulating peripheral leukocyte migration into the brain in inflammatory conditions. Strategies restraining the release of EVs by activated astrocytes or modulating the composition of ADEVs are likely beneficial for treating neurodegenerative diseases. Also, periodic analyses of ADEVs in the blood is useful for detecting astrocyte-specific biomarkers in different neurological conditions and for monitoring disease progression and remission with distinct therapeutic approaches.
Identifiants
pubmed: 32289328
pii: S0168-3659(20)30230-3
doi: 10.1016/j.jconrel.2020.04.017
pmc: PMC7299747
mid: NIHMS1587790
pii:
doi:
Substances chimiques
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-239Subventions
Organisme : NINDS NIH HHS
ID : R01 NS106907
Pays : United States
Informations de copyright
Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declared that there is no conflict of interest.
Références
J Neurosci. 2007 Nov 7;27(45):12331-40
pubmed: 17989297
Brain Struct Funct. 2017 Jul;222(5):2017-2029
pubmed: 28280934
Acta Neuropathol. 2010 Jan;119(1):7-35
pubmed: 20012068
Glia. 2016 Jun;64(6):896-910
pubmed: 26992135
PLoS One. 2011 Feb 09;6(2):e16659
pubmed: 21347424
Behav Brain Res. 2012 Feb 14;227(2):440-9
pubmed: 21536078
Front Neurosci. 2018 Jul 19;12:487
pubmed: 30072868
Curr Issues Mol Biol. 2010;12(2):63-86
pubmed: 19767651
J Biol Chem. 2002 Apr 26;277(17):15107-12
pubmed: 11842086
J Exp Neurosci. 2016 Aug 08;10(Suppl 1):1-9
pubmed: 27547038
Neurobiol Aging. 2014 Aug;35(8):1792-800
pubmed: 24650793
Alzheimers Dement (Amst). 2019 Jan 09;11:61-66
pubmed: 31032394
Pharmacol Ther. 2018 Aug;188:1-11
pubmed: 29476772
J Neurosci. 2005 Oct 19;25(42):9735-45
pubmed: 16237177
Int J Mol Sci. 2019 Dec 26;21(1):
pubmed: 31888012
Trends Cell Biol. 2001 Jan;11(1):6-10
pubmed: 11146277
J Neuroinflammation. 2019 Jul 4;16(1):136
pubmed: 31272469
Oncotarget. 2015 Sep 15;6(27):24178-91
pubmed: 26172304
J Cell Sci. 2008 Sep 15;121(Pt 18):3042-51
pubmed: 18713831
Cell Rep. 2016 Oct 11;17(3):645-652
pubmed: 27732842
J Cell Biol. 2015 Nov 23;211(4):897-911
pubmed: 26598621
Traffic. 2019 Nov;20(11):815-828
pubmed: 31418976
EBioMedicine. 2019 Feb;40:626-635
pubmed: 30711519
Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
J Neuroimmune Pharmacol. 2018 Sep;13(3):330-344
pubmed: 29497921
Neuron. 1996 Mar;16(3):675-86
pubmed: 8785064
Brain Behav Immun. 2019 Oct;81:430-443
pubmed: 31255677
Glia. 2000 Oct;32(1):1-14
pubmed: 10975906
Neurobiol Aging. 2014 Jul;35(7):1632-42
pubmed: 24612673
Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4146-51
pubmed: 22315426
Biochem Biophys Res Commun. 2008 Feb 29;367(1):109-15
pubmed: 18162177
Adv Drug Deliv Rev. 2013 Mar;65(3):331-5
pubmed: 22750807
Cell. 1993 Nov 19;75(4):661-70
pubmed: 7902212
Endocr Rev. 2001 Apr;22(2):153-83
pubmed: 11294822
FASEB J. 2016 Nov;30(11):3853-3859
pubmed: 27511944
J Neurochem. 2015 May;133(4):558-71
pubmed: 25692227
Trends Immunol. 2002 Nov;23(11):509-12
pubmed: 12401394
Cell Mol Life Sci. 2008 Aug;65(15):2372-84
pubmed: 18500448
J Neurovirol. 2016 Dec;22(6):774-788
pubmed: 27173397
Methods. 2012 Feb;56(2):293-304
pubmed: 22285593
Curr Neurovasc Res. 2004 Jul;1(3):261-7
pubmed: 16181076
Nat Rev Neurosci. 2005 Aug;6(8):626-40
pubmed: 16025096
Cereb Cortex. 2017 Jan 1;27(1):24-33
pubmed: 28365776
Science. 2008 Feb 29;319(5867):1244-7
pubmed: 18309083
Prog Neurobiol. 2019 Apr;175:96-106
pubmed: 30685501
Ann Neurol. 2018 Mar;83(3):544-552
pubmed: 29406582
J Neurotrauma. 1996 Jun;13(6):309-16
pubmed: 8835798
Aging Cell. 2008 Aug;7(4):506-15
pubmed: 18419796
Neuron. 1992 Mar;8(3):521-9
pubmed: 1312849
Front Neurosci. 2019 Jul 02;13:698
pubmed: 31312118
Front Aging Neurosci. 2018 Aug 21;10:254
pubmed: 30186153
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):170-5
pubmed: 26699510
Glia. 2020 Jan;68(1):128-144
pubmed: 31469478
Neurobiol Dis. 2019 Oct;130:104512
pubmed: 31229685
Front Cell Neurosci. 2018 Nov 27;12:432
pubmed: 30538622
Curr Neuropharmacol. 2009 Mar;7(1):1-8
pubmed: 19721814
EBioMedicine. 2018 Dec;38:273-282
pubmed: 30472088
J Neuroinflammation. 2012 Aug 16;9:198
pubmed: 22894638
Trends Neurosci. 2019 May;42(5):361-372
pubmed: 30926143
Neurobiol Dis. 2019 Oct;130:104511
pubmed: 31212068
Int J Mol Med. 2008 Jan;21(1):63-7
pubmed: 18097617
Am J Pathol. 1999 Mar;154(3):927-36
pubmed: 10079271
EMBO J. 2016 Feb 1;35(3):239-57
pubmed: 26758544
J Control Release. 2016 Feb 28;224:165-175
pubmed: 26774220
J Extracell Vesicles. 2014 Dec 22;3:26913
pubmed: 25536934
Cell Discov. 2018 Apr 24;4:19
pubmed: 29707233
Dev Cell. 2011 Oct 18;21(4):708-21
pubmed: 21962903
J Biol Chem. 2013 May 31;288(22):15699-711
pubmed: 23592792
J Neurosci. 2005 Dec 7;25(49):11330-9
pubmed: 16339028
Stem Cells. 2017 Sep;35(9):2071-2082
pubmed: 28733998
Handb Exp Pharmacol. 2013;(215):57-76
pubmed: 23579449
Glia. 2005 Aug 15;51(3):173-86
pubmed: 15800930
Cell Stress Chaperones. 1996 Sep;1(3):161-6
pubmed: 9222601
J Extracell Vesicles. 2019 Jun 27;8(1):1627164
pubmed: 31275532
Exp Gerontol. 2015 Jul;67:19-47
pubmed: 25868396
Curr Pharm Des. 2019;25(33):3500-3505
pubmed: 31612823
FEBS J. 2013 Mar;280(5):1200-13
pubmed: 23289620
Front Cell Neurosci. 2019 Jan 10;12:526
pubmed: 30687015
Front Cell Neurosci. 2013 Dec 10;7:251
pubmed: 24368897
J Neurosci. 2008 Dec 3;28(49):13112-24
pubmed: 19052202
Methods Mol Biol. 2012;814:3-7
pubmed: 22144296
Neuron. 1994 Sep;13(3):713-25
pubmed: 7917301
J Cell Sci. 2004 Jun 1;117(Pt 13):2641-51
pubmed: 15169835
Nat Rev Neurosci. 2006 Jan;7(1):41-53
pubmed: 16371949
Eur J Neurosci. 2007 Oct;26(7):1765-79
pubmed: 17883411
Neurotherapeutics. 2015 Apr;12(2):352-63
pubmed: 25652699
Mol Ther Nucleic Acids. 2018 Dec 7;13:450-463
pubmed: 30388619
J Neurochem. 2015 Sep;134(6):982-1007
pubmed: 26096891
Immunity. 2017 Jun 20;46(6):957-967
pubmed: 28636962
J Neurosci. 2007 Jun 13;27(24):6473-7
pubmed: 17567808
Nat Rev Neurosci. 2015 May;16(5):249-63
pubmed: 25891508
J Neurooncol. 2013 May;113(1):1-11
pubmed: 23456661
Stem Cells Transl Med. 2015 Oct;4(10):1131-43
pubmed: 26339036
Regen Med. 2009 Nov;4(6):865-77
pubmed: 19903005
Methods Mol Biol. 2019;1938:19-33
pubmed: 30617970
J Neuroimmune Pharmacol. 2013 Mar;8(1):301-11
pubmed: 23238794
Cell Death Dis. 2018 Mar 5;9(3):363
pubmed: 29507357
Lancet Infect Dis. 2013 Nov;13(11):976-86
pubmed: 24156898
Lancet Neurol. 2010 Oct;9(10):995-1007
pubmed: 20864052
Nat Rev Neurol. 2016 Jun;12(6):346-57
pubmed: 27174238
J Neurosci Res. 1996 Oct 01;46(1):58-66
pubmed: 8892106
Virol J. 2011 Jan 22;8:35
pubmed: 21255447
Neuroscience. 2005;136(4):991-1001
pubmed: 16203102
J Cell Biol. 2002 Sep 30;158(7):1277-85
pubmed: 12356871
J Neurosci. 2002 Jan 1;22(1):183-92
pubmed: 11756501
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E968-77
pubmed: 26858453
Biochem Biophys Res Commun. 2012 Feb 3;418(1):27-32
pubmed: 22222374
FASEB J. 2015 Feb;29(2):589-96
pubmed: 25342129
J Neuroimmune Pharmacol. 2014 Mar;9(2):92-101
pubmed: 24057103
Endocr Rev. 1997 Feb;18(1):26-45
pubmed: 9034785
Stem Cells Transl Med. 2019 May;8(5):490-499
pubmed: 30706999
Proteomics Clin Appl. 2015 Apr;9(3-4):358-67
pubmed: 25684126
Cell Adh Migr. 2012 Nov-Dec;6(6):541-6
pubmed: 23076132
EMBO J. 2009 Apr 22;28(8):1043-54
pubmed: 19300439
Brain. 2011 Sep;134(Pt 9):2627-41
pubmed: 21908873
Nat Med. 2003 Apr;9(4):453-7
pubmed: 12612547
EMBO J. 2015 Oct 1;34(19):2398-407
pubmed: 26311197
Nat Neurosci. 2007 May;10(5):615-22
pubmed: 17435755
J Immunol. 1999 Jul 15;163(2):603-10
pubmed: 10395647
Neurobiol Aging. 2008 Jan;29(1):129-47
pubmed: 17092610
J Biol Chem. 2013 Apr 26;288(17):11649-61
pubmed: 23463506
Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10016-20
pubmed: 1438191
Glia. 2010 Aug;58(10):1235-46
pubmed: 20544859
Neurosci Biobehav Rev. 1997 Mar;21(2):135-42
pubmed: 9062936
Stroke. 2018 Oct;49(10):2483-2494
pubmed: 30355116
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Epilepsy Behav. 2019 Oct 18;:106499
pubmed: 31636006
J Cereb Blood Flow Metab. 2017 Apr;37(4):1182-1191
pubmed: 28155572
Philos Trans R Soc Lond B Biol Sci. 1999 Feb 28;354(1381):269-79
pubmed: 10212475
J Neurochem. 2005 Aug;94(3):597-606
pubmed: 15992387
Cell Stress Chaperones. 2004 Mar;9(1):88-98
pubmed: 15270081
Nat Med. 2018 Jul;24(7):931-938
pubmed: 29892066
J Mol Neurosci. 2012 Sep;48(1):77-85
pubmed: 22552714
J Comp Neurol. 1994 Apr 15;342(3):449-62
pubmed: 8021345
Cell. 2013 Mar 14;152(6):1298-307
pubmed: 23498938
Mol Neurodegener. 2016 May 12;11(1):38
pubmed: 27176225
Cell. 2017 Jan 26;168(3):427-441.e21
pubmed: 28111074
FASEB J. 2002 Apr;16(6):601-3
pubmed: 11919167
Cell Mol Life Sci. 2013 Sep;70(17):3211-27
pubmed: 23543276
Semin Cancer Biol. 2014 Oct;28:3-13
pubmed: 24769058
Sci Signal. 2017 Apr 04;10(473):
pubmed: 28377412
J Cereb Blood Flow Metab. 2018 May;38(5):767-779
pubmed: 28524762
PLoS Biol. 2013 Jul;11(7):e1001604
pubmed: 23874151
J Biol Chem. 2013 Feb 22;288(8):5914-26
pubmed: 23293020
Nat Med. 2000 Apr;6(4):435-42
pubmed: 10742151
EMBO J. 2011 Jun 1;30(11):2115-29
pubmed: 21527913
Brain Behav Immun. 2017 Feb;60:220-232
pubmed: 27847282
Neuron. 2015 Dec 2;88(5):861-877
pubmed: 26637795
Nat Med. 2006 Dec;12(12):1380-9
pubmed: 17099709
J Alzheimers Dis. 2017;60(1):305-321
pubmed: 28826183
Biomed Res Int. 2015;2015:152926
pubmed: 26583089
FASEB J. 2018 Feb;32(2):654-668
pubmed: 28970251
Stem Cells. 2007 Aug;25(8):2104-17
pubmed: 17510219
Acta Neuropathol. 1982;57(2-3):239-42
pubmed: 6812382
Dev Neurobiol. 2007 Nov;67(13):1815-29
pubmed: 17701989
Exp Cell Res. 2009 May 15;315(9):1584-92
pubmed: 18930046
Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3536-E3545
pubmed: 28396435
J Neurosurg. 2015 Apr;122(4):856-67
pubmed: 25594326
Nat Rev Neurol. 2016 Aug;12(8):439-54
pubmed: 27364743
J Neurochem. 2007 Dec;103(6):2164-76
pubmed: 17868300
Stroke. 2018 May;49(5):1248-1256
pubmed: 29650593
J Neural Transm (Vienna). 2010 Jan;117(1):1-4
pubmed: 19680595
Physiol Rev. 2013 Oct;93(4):1621-57
pubmed: 24137018
Protein Cell. 2015 Jul;6(7):529-540
pubmed: 26091620
Trends Neurosci. 2018 Jun;41(6):360-372
pubmed: 29605090
Cell Mol Life Sci. 2013 May;70(10):1753-61
pubmed: 23475070
Cell Death Dis. 2017 Jan 12;8(1):e2542
pubmed: 28079886
Neurobiol Aging. 2015 May;36(5):1820-33
pubmed: 25784209
Glia. 2020 Jan;68(1):5-26
pubmed: 31058383
Int J Mol Sci. 2018 Jan 17;19(1):
pubmed: 29342116
J Biol Chem. 2019 Mar 8;294(10):3744-3759
pubmed: 30635404
J Lipid Res. 1999 Mar;40(3):447-55
pubmed: 10064733
Trends Neurosci. 1999 May;22(5):208-15
pubmed: 10322493
Cell Cycle. 2010 Jan 15;9(2):269-73
pubmed: 20023409
J Biol Chem. 2002 Apr 26;277(17):15028-34
pubmed: 11836257
Glia. 1994 Jun;11(2):156-72
pubmed: 7523291
Cell Death Dis. 2012 Aug 30;3:e381
pubmed: 22932723
J Neurosci. 2011 May 18;31(20):7275-90
pubmed: 21593312
Nature. 2018 Sep;561(7723):396-400
pubmed: 30158698
Biol Chem. 2003 Feb;384(2):267-79
pubmed: 12675520
Stem Cells Int. 2017;2017:1719050
pubmed: 29081809