Non-pharmacological and pharmacological approaches for psychiatric disorders: Re-appraisal and insights from zebrafish models.
Animals
Anti-Anxiety Agents
/ therapeutic use
Antidepressive Agents
/ therapeutic use
Behavior, Animal
/ drug effects
Complementary Therapies
/ methods
Disease Models, Animal
Female
Humans
Male
Mental Disorders
/ drug therapy
Rodentia
Stress, Psychological
/ complications
Treatment Outcome
Zebrafish
Acute and chronic stress
Animal model
Environmental enrichment
Mental illness
Psychopharmacotherapy
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
24
02
2020
accepted:
07
04
2020
pubmed:
15
4
2020
medline:
22
1
2021
entrez:
15
4
2020
Statut:
ppublish
Résumé
Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay.
Identifiants
pubmed: 32289330
pii: S0091-3057(20)30116-7
doi: 10.1016/j.pbb.2020.172928
pii:
doi:
Substances chimiques
Anti-Anxiety Agents
0
Antidepressive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
172928Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.