The Role of Platelet Transfusions After Intracranial Hemorrhage in Patients on Antiplatelet Agents: A Systematic Review and Meta-Analysis.

Brain Injuries, Traumatic / drug therapy Clopidogrel / therapeutic use Humans Intracranial Hemorrhages / therapy Platelet Aggregation Inhibitors / therapeutic use Platelet Transfusion / methods
Antiplatelet agents Antiplatelet drugs Disability Intracranial hemorrhage Mortality Neurologic outcome Platelet Platelet transfusion Traumatic brain injury

Journal

World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275

Informations de publication

Date de publication:
09 2020
Historique:
received: 01 12 2019
revised: 28 03 2020
accepted: 30 03 2020
pubmed: 15 4 2020
medline: 8 1 2021
entrez: 15 4 2020
Statut: ppublish

Résumé

The evidence suggests that antiplatelet agents (APA) slightly increase the risk of death and disease progression in patients with traumatic brain injury or spontaneous intracranial hemorrhage (ICH). There is little evidence that APA reversal with platelet (PLT) transfusion may improve the outcome. In this systematic review and meta-analysis, our goal was to evaluate the differences in mortality, severe disability, and hematoma expansion related to PLT transfusion. We retrieved randomized or cohort studies comparing adult patients on APA with traumatic brain injury or ICH who were treated with PLT or not. We calculated the standardized risk difference and 95% confidence interval. A random-effects model was applied to analyze the data. The heterogeneity of the retrieved trials was evaluated through the I

Identifiants

DOI: 10.1016/j.wneu.2020.03.216 PMID: 32289507
pubmed: 32289507
pii: S1878-8750(20)30687-2
doi: 10.1016/j.wneu.2020.03.216
pii:
doi:

Substances chimiques

Platelet Aggregation Inhibitors 0
Clopidogrel A74586SNO7

Types de publication

Journal Article Meta-Analysis Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

455-466.e13

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Etrusca Brogi (E)

Department of Anaesthesia and Intensive Care, University of Pisa, Pisa, Italy; Department of Anaesthesia and Intensive Care, Bufalini Hospital, Cesena, Italy. Electronic address: etruscabrogi@gmail.com.

Davide Corbella (D)

NeuroTrauma Intensive Care Unit, Department of Anaesthesia, Emergency and Critical Care, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Federico Coccolini (F)

Department of Surgery, University of Pisa, Pisa, Italy.

Emiliano Gamberini (E)

Department of Anaesthesia and Intensive Care, Bufalini Hospital, Cesena, Italy.

Emanuele Russo (E)

Department of Anaesthesia and Intensive Care, Bufalini Hospital, Cesena, Italy.

Vanni Agnoletti (V)

Department of Anaesthesia and Intensive Care, Bufalini Hospital, Cesena, Italy.

Francesco Forfori (F)

Department of Anaesthesia and Intensive Care, University of Pisa, Pisa, Italy.

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Classifications MeSH

questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › The Role of Platelet Transfusions After...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Thiénopyridines › Ticlopidine › Clopidogrel › The Role of Platelet Transfusions After...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Role of Platelet Transfusions After...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hémorragie › Hémorragies intracrâniennes › The Role of Platelet Transfusions After...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Antiagrégants plaquettaires › The Role of Platelet Transfusions After...
questionsmedicales.fr › Thérapeutique › Biothérapie › Transfusion sanguine › Transfusion de composants du sang › Transfusion de plaquettes › The Role of Platelet Transfusions After...