The effect of polymorphisms in startle-related genes on anxiety symptom severity.

Anxiety / genetics Anxiety Disorders Endophenotypes Humans Polymorphism, Single Nucleotide / genetics Receptors, G-Protein-Coupled / genetics Reflex, Startle / genetics
Anxiety Endophenotypes Genetics Single nucleotide polymorphisms Startle response

Journal

Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331

Informations de publication

Date de publication:
06 2020
Historique:
received: 09 01 2020
revised: 24 03 2020
accepted: 31 03 2020
pubmed: 15 4 2020
medline: 15 5 2021
entrez: 15 4 2020
Statut: ppublish

Résumé

Given the limited effectiveness of treatments for pathological anxiety, there is a pressing need to identify genetic markers that can aid the precise selection of treatments and optimize treatment response. Anxiety and startle response levels demonstrate a direct relationship, and previous literature suggests that exaggerated startle reactivity may serve as an endophenotype of pathological anxiety. In addition, genetic variants related to startle reactivity may play a role in the etiology of pathological anxiety. In the current study, we selected 22 single nucleotide polymorphisms (SNPs) related to startle reactivity in the literature, and examined their association with anxiety symptom severity across psychiatric disorders (n = 508), and in a subset of patients with an anxiety disorder (n = 298). Overall, none of the SNPs pass correction for multiple independent tests. However, across psychiatric patients, rs6323 from the monoamine oxidase A (MAOA) gene and rs324981 from the neuropeptide S receptor 1 (NPSR1) gene were nominally associated with baseline anxiety symptom severity (p = 0.017, 0.023). These preliminary findings provide support for investigating startle-related genetic variants to identify biomarkers of anxiety symptom severity.

Identifiants

DOI: 10.1016/j.jpsychires.2020.03.019 PMID: 32289651
pubmed: 32289651
pii: S0022-3956(20)30015-7
doi: 10.1016/j.jpsychires.2020.03.019
pii:
doi:

Substances chimiques

NPSR1 protein, human 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

144-151

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest JLK is a member of the Scientific Advisory Board of Myriad Neuroscience (unpaid) and holds several patents relating to pharmacogenetic tests for psychiatric medications. The remaining authors have no conflicts of interest to disclose.

Auteurs

Julia Tomasi (J)

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. Electronic address: Julia.Tomasi@camh.ca.

Clement C Zai (CC)

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Gwyneth Zai (G)

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; General Adult Psychiatry and Health Systems Division, CAMH, Toronto, ON, Canada.

Deanna Herbert (D)

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.

Nicole King (N)

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.

Natalie Freeman (N)

Campbell Family Mental Health Research Institute and Krembil Centre for Neuroinformatics, CAMH, Toronto, ON, Canada.

James L Kennedy (JL)

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Arun K Tiwari (AK)

Molecular Brain Science Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address: Arun.Tiwari@camh.ca.

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Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › The effect of polymorphisms in startle-related...
questionsmedicales.fr › Troubles mentaux › Troubles anxieux › The effect of polymorphisms in startle-related...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Endophénotypes › The effect of polymorphisms in startle-related...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The effect of polymorphisms in startle-related...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › The effect of polymorphisms in startle-related...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › The effect of polymorphisms in startle-related...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Réflexe › Réflexe de sursaut › The effect of polymorphisms in startle-related...