Transcriptional Profiling of the Adult Hair Follicle Mesenchyme Reveals R-spondin as a Novel Regulator of Dermal Progenitor Function.
Biological Sciences
Developmental Biology
Stem Cells Research
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
24 Apr 2020
24 Apr 2020
Historique:
received:
30
07
2019
revised:
18
10
2019
accepted:
24
03
2020
pubmed:
15
4
2020
medline:
15
4
2020
entrez:
15
4
2020
Statut:
ppublish
Résumé
The adult hair follicle (HF) undergoes successive regeneration driven by resident epithelial stem cells and neighboring mesenchyme. Recent work described the existence of HF dermal stem cells (hfDSCs), but the genetic regulation of hfDSCs and their daughter cell lineages in HF regeneration remains unknown. Here we prospectively isolate functionally distinct mesenchymal compartment in the HF (dermal cup [DC; includes hfDSCs] and dermal papilla) and define the transcriptional programs involved in hfDSC function and acquisition of divergent mesenchymal fates. From this, we demonstrate cross-compartment mesenchymal signaling within the HF niche, whereby DP-derived R-spondins act to stimulate proliferation of both hfDSCs and epithelial progenitors during HF regeneration. Our findings describe unique transcriptional programs that underlie the functional heterogeneity among specialized fibroblasts within the adult HF and identify a novel regulator of mesenchymal progenitor function during tissue regeneration.
Identifiants
pubmed: 32289736
pii: S2589-0042(20)30203-0
doi: 10.1016/j.isci.2020.101019
pmc: PMC7155209
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101019Subventions
Organisme : NICHD NIH HHS
ID : R01 HD091068
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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