Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis.
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
15
4
2020
pubmed:
15
4
2020
medline:
22
12
2020
Statut:
ppublish
Résumé
Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.
Identifiants
pubmed: 32289858
doi: 10.1055/s-0040-1708035
doi:
Types de publication
Consensus Development Conference
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
538-564Subventions
Organisme : Marie Skłodowska-Curie grant agreement number 766118
ID : European Union's Horizon 2020 research and innovation program
Organisme : CVON2014-09, RACE V, reappraisal of AF: interaction between hypercoagulability, electrical remodeling, and vascular destabilization in the progression of AF
ID : Netherlands Heart Foundation
Investigateurs
Lina Badimon
(L)
Christoph Binder
(C)
Marc Hoylaerts
(M)
Peter Karlheinz
(P)
Rory Koenen
(R)
Gregory Y H Lip
(GYH)
Steffen Massberg
(S)
Philipp von Hundelshausen
(P)
Christian Weber
(C)
Johann Wojta
(J)
Informations de copyright
Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
None declared.