Higher Urinary Dopamine Concentration is Associated with Greater Ad Libitum Energy Intake in Humans.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
20
11
2019
revised:
17
02
2020
accepted:
18
02
2020
pubmed:
15
4
2020
medline:
17
9
2020
entrez:
15
4
2020
Statut:
ppublish
Résumé
This study aimed to assess the relationship between dopamine, a neurotransmitter involved in feeding behavior, and ad libitum energy intake in humans. Healthy individuals (n = 158; 72 Native American, 50 white, 18 black, and 18 Hispanic participants; BMI: 33 [SD 9] kg/m Urinary dopamine excretion rate was on average 346 ± 106 μg over 24 hours and was positively correlated with BMI (r = 0.28, P < 0.0001). Higher dopamine concentrations were associated with lower cognitive restraint (ρ = -0.25, P = 0.005) and greater total ad libitum energy intake (r = 0.29, P = 0.0002). However, after adjustment for anthropometrics, in black and white cohorts, higher dopamine concentrations were associated with greater total ad libitum energy intake (r = 0.70, P = 0.001 and r = 0.33, P = 0.02, respectively), whereas no associations were observed in Native American or Hispanic cohorts (all P > 0.3). Higher urinary dopamine concentrations are associated with greater ad libitum energy intake, indicating a role for dopamine in the reward pathway regulating human feeding behavior.
Identifiants
pubmed: 32289874
doi: 10.1002/oby.22781
pmc: PMC7180122
mid: NIHMS1565477
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
953-961Subventions
Organisme : NIDDK NIH HHS
ID : DK075034-09
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK075034
Pays : United States
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : "Rita Levi Montalcini for young researchers" p
Pays : International
Organisme : NIDDK NIH HHS
ID : DK069091-12
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA DK069091
Pays : United States
Informations de copyright
© 2020 The Obesity Society. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Références
Behav Neurosci. 2007 Oct;121(5):877-86
pubmed: 17907820
Obesity (Silver Spring). 2006 Feb;14 Suppl 1:1S-8S
pubmed: 16642956
Neurosci Biobehav Rev. 2011 Jan;35(3):635-44
pubmed: 20696183
Am J Clin Nutr. 1991 Jun;53(6):1368-71
pubmed: 2035463
Nat Genet. 2000 May;25(1):102-4
pubmed: 10802666
Lancet. 2001 Feb 3;357(9253):354-7
pubmed: 11210998
Cell Commun Signal. 2013 May 17;11(1):34
pubmed: 23683503
Mol Psychiatry. 2014 Oct;19(10):1078-84
pubmed: 25199919
Nat Neurosci. 2010 May;13(5):635-41
pubmed: 20348917
Life Sci. 1980 Jan 28;26(4):253-9
pubmed: 7354704
Diabetes. 2001 Apr;50(4):901-4
pubmed: 11289060
Trends Cogn Sci. 2011 Jan;15(1):37-46
pubmed: 21109477
Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):803-13
pubmed: 9723121
Int J Obes (Lond). 2014 Feb;38(2):243-51
pubmed: 23736368
Acta Physiol Scand Suppl. 1971;367:95-122
pubmed: 4332694
Eur Neuropsychopharmacol. 2018 Jun;28(6):719-731
pubmed: 29705023
Nutrition. 2000 Oct;16(10):843-57
pubmed: 11054589
J Clin Invest. 1995 Sep;96(3):1658-63
pubmed: 7657836
Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2764-9
pubmed: 24550305
Cell. 1995 Dec 29;83(7):1197-209
pubmed: 8548806
Neuroscience. 1990;39(1):17-24
pubmed: 2128534
Ideggyogy Sz. 2003 Sep 20;56(9-10):288-302
pubmed: 14608950
Diabetes Care. 1997 Jul;20(7):1183-97
pubmed: 9203460
Open Access J Urol. 2010 Oct 07;2:177-83
pubmed: 24198626
Pharmacol Biochem Behav. 1996 Jan;53(1):221-6
pubmed: 8848454
Neuroimage. 2003 Aug;19(4):1709-15
pubmed: 12948725
Endocr Rev. 2017 Aug 1;38(4):267-296
pubmed: 28898979
Obesity (Silver Spring). 2017 Feb;25(2):332-337
pubmed: 28000375
N Engl J Med. 2011 Feb 24;364(8):719-29
pubmed: 21345101
Obesity (Silver Spring). 2019 May;27(5):691-699
pubmed: 31012296
Nature. 2000 Apr 6;404(6778):661-71
pubmed: 10766253
Physiol Behav. 1998 Mar;63(5):919-28
pubmed: 9618017
J Neurosci. 1991 Dec;11(12):3822-9
pubmed: 1744692
Nat Rev Neurosci. 2011 Oct 20;12(11):638-51
pubmed: 22011680
Clin Chem. 2005 Feb;51(2):472-3; discussion 473-4
pubmed: 15681566
J Abnorm Psychol. 2008 Nov;117(4):924-35
pubmed: 19025237
Int J Obes (Lond). 2019 Jul;43(7):1456-1465
pubmed: 30651576
Can J Physiol Pharmacol. 1980 Jan;58(1):22-7
pubmed: 7378904
Ann N Y Acad Sci. 2008;1129:35-46
pubmed: 18591467
Trends Pharmacol Sci. 1992 May;13(5):177-84
pubmed: 1604710
Clin Sci (Lond). 1982 May;62(5):439-48
pubmed: 6804154
Am J Clin Nutr. 2010 Feb;91(2):343-8
pubmed: 19923376