PD-L1-PD-1 Pathway in the Pathophysiology of Multiple Myeloma.
AKT pathway
PD-1
PD-L1 (B7-H1)
immune checkpoint inhibitors
monoclonal gammopathy of undetermined significance (MGUS)
multiple myeloma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
10 Apr 2020
10 Apr 2020
Historique:
received:
08
03
2020
revised:
03
04
2020
accepted:
07
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
PD-L1 expressed on tumor cells contributes to disease progression with evasion from tumor immunity. Plasma cells from multiple myeloma (MM) patients expressed higher levels of PD-L1 compared with healthy volunteers and monoclonal gammopathy of undetermined significance (MGUS) patients, and its expression is significantly upregulated in relapsed/refractory patients. Furthermore, high PD-L1 expression is induced by the myeloma microenvironment and PD-L1
Identifiants
pubmed: 32290052
pii: cancers12040924
doi: 10.3390/cancers12040924
pmc: PMC7226506
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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