Analysis of Nicotine Metabolites in Hair and Nails Using QuEChERS Method Followed by Liquid Chromatography-Tandem Mass Spectrometry.
LC–MS/MS
QuEChERS
bioanalysis
hair
nail
nicotine metabolites
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Apr 2020
11 Apr 2020
Historique:
received:
20
03
2020
revised:
05
04
2020
accepted:
09
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
8
1
2021
Statut:
epublish
Résumé
Many studies have analyzed nicotine metabolites in blood and urine to determine the toxicity caused by smoking, and assess exposure to cigarettes. Recently, hair and nails have been used as alternative samples for the evaluation of smoking, as not only do they reflect long-term exposure but they are also stable and easy to collect. Liquid-liquid or solid-phase extraction has mainly been used to detect nicotine metabolites in biological samples; however, these have disadvantages, such as the use of toxic organic solvents and complex pretreatments. In this study, a modified QuEChERS method was proposed for the first time to prepare samples for the detection of nicotine metabolite cotinine (COT) and
Identifiants
pubmed: 32290380
pii: molecules25081763
doi: 10.3390/molecules25081763
pmc: PMC7221804
pii:
doi:
Substances chimiques
hydroxycotinine
27323-64-4
Nicotine
6M3C89ZY6R
Cotinine
K5161X06LL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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