Natural Killer Cells: Tumor Surveillance and Signaling.
NK cells
Natural Killer cells
activating receptors
immune surveillance
inhibitory receptors
signaling
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Apr 2020
11 Apr 2020
Historique:
received:
04
03
2020
revised:
03
04
2020
accepted:
09
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate ability to detect and kill tumorigenic cells. The decision to kill is determined by the expression of a myriad of activating and inhibitory receptors on the NK cell surface. Cell-to-cell engagement results in either self-tolerance or a cytotoxic response, governed by a fine balance between the signaling cascades downstream of the activating and inhibitory receptors. To evade a cytotoxic immune response, tumor cells can modulate the surface expression of receptor ligands and additionally, alter the conditions in the tumor microenvironment (TME), tilting the scales toward a suppressed cytotoxic NK response. To fully harness the killing power of NK cells for clinical benefit, we need to understand what defines the threshold for activation and what is required to break tolerance. This review will focus on the intracellular signaling pathways activated or suppressed in NK cells and the roles signaling intermediates play during an NK cytotoxic response.
Identifiants
pubmed: 32290478
pii: cancers12040952
doi: 10.3390/cancers12040952
pmc: PMC7226588
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Victorian State Government Operational Infrastructure Support and the Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support scheme
ID : x
Organisme : National Health and Medical Research Council
ID : 1124784
Déclaration de conflit d'intérêts
S.N. receives research funding from and has licensed a patent to a pharmaceutical partner with interest in NK cells as therapeutic targets. The funders had no role in the content of the review or the writing of the manuscript.
Références
Eur J Immunol. 1997 Mar;27(3):660-5
pubmed: 9079806
Sci Signal. 2016 May 24;9(429):ra54
pubmed: 27221712
Eur J Immunol. 1999 May;29(5):1656-66
pubmed: 10359120
Mol Biol Cell. 2010 Jul 1;21(13):2241-56
pubmed: 20444980
J Immunol. 2005 Dec 15;175(12):7996-8002
pubmed: 16339536
J Immunol. 2005 Dec 15;175(12):7796-9
pubmed: 16339513
J Immunol. 2005 Apr 15;174(8):4789-96
pubmed: 15814704
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5744-9
pubmed: 9159144
J Exp Med. 2003 Aug 18;198(4):557-67
pubmed: 12913096
Blood. 2012 Apr 19;119(16):3734-43
pubmed: 22383801
Immunobiology. 2018 Jan;223(1):57-63
pubmed: 29055565
Mol Immunol. 2008 Jul;45(12):3446-53
pubmed: 18479751
Nat New Biol. 1973 Mar 28;242(117):111-3
pubmed: 4541031
J Biol Chem. 2000 Jul 21;275(29):22127-35
pubmed: 10801860
Blood. 2009 Sep 24;114(13):2657-66
pubmed: 19628705
J Biol Chem. 2007 Feb 9;282(6):3418-22
pubmed: 17138568
Cancer Res. 2006 Mar 1;66(5):2520-6
pubmed: 16510567
Nature. 2015 Jan 15;517(7534):386-90
pubmed: 25363763
Eur J Immunol. 2013 Sep;43(9):2473-83
pubmed: 23696226
J Exp Med. 1998 Dec 7;188(11):2083-90
pubmed: 9841922
Immunity. 1999 Jul;11(1):67-77
pubmed: 10435580
J Exp Med. 1990 May 1;171(5):1393-405
pubmed: 1692078
Science. 1999 Jul 30;285(5428):730-2
pubmed: 10426994
J Immunother Cancer. 2019 Aug 26;7(1):223
pubmed: 31446896
Mol Ther. 2019 Jun 5;27(6):1114-1125
pubmed: 30962163
Glycobiology. 2000 Apr;10(4):431-8
pubmed: 10764831
J Immunol. 2004 Jan 15;172(2):899-906
pubmed: 14707061
J Immunol. 2001 Jun 15;166(12):7219-28
pubmed: 11390470
Mol Immunol. 2011 Oct;49(1-2):402-6
pubmed: 21955987
J Exp Med. 2005 Oct 3;202(7):1001-12
pubmed: 16203869
J Immunol. 2005 Dec 15;175(12):7791-5
pubmed: 16339512
Oncotarget. 2019 Feb 15;10(14):1399-1406
pubmed: 30858925
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20579-84
pubmed: 22158902
Cancer Res. 2014 Jun 15;74(12):3199-204
pubmed: 24830719
Cancer. 2010 Apr 15;116(8):1953-63
pubmed: 20186824
Blood. 2013 Oct 24;122(17):2921-2
pubmed: 24159160
Nat Immunol. 2009 Mar;10(3):297-305
pubmed: 19151721
Nat Immunol. 2003 Jun;4(6):557-64
pubmed: 12740575
J Clin Invest. 2018 Oct 1;128(10):4654-4668
pubmed: 30198904
Jpn J Cancer Res. 1997 Jul;88(7):652-9
pubmed: 9310138
Nat Commun. 2014 Oct 30;5:5108
pubmed: 25355530
Int J Cancer. 1975 Aug 15;16(2):230-9
pubmed: 1080480
J Exp Med. 1997 Dec 15;186(12):1965-74
pubmed: 9396765
J Exp Med. 1999 Mar 1;189(5):787-96
pubmed: 10049942
Oncotarget. 2017 Apr 19;8(31):51936-51945
pubmed: 28881701
Science. 2011 Jan 7;331(6013):44-9
pubmed: 21212348
Proc Natl Acad Sci U S A. 2005 May 24;102(21):7641-6
pubmed: 15894612
Nature. 1998 Feb 19;391(6669):795-9
pubmed: 9486650
Front Immunol. 2013 Apr 16;4:90
pubmed: 23596445
J Immunol. 2005 Oct 1;175(7):4226-35
pubmed: 16177062
Front Immunol. 2014 Jun 02;5:214
pubmed: 24917862
Immunity. 1999 Nov;11(5):603-13
pubmed: 10591185
Annu Rev Immunol. 2008;26:677-704
pubmed: 18173375
J Immunol. 2012 Mar 15;188(6):2509-15
pubmed: 22308311
Cancer Sci. 2010 May;101(5):1326-30
pubmed: 20331633
Immunity. 2008 Oct 17;29(4):578-88
pubmed: 18835194
Eur J Immunol. 2020 Jan;50(1):48-55
pubmed: 31531847
Immunol Today. 1990 Jul;11(7):237-44
pubmed: 2201309
J Immunol. 2001 Oct 15;167(8):4358-67
pubmed: 11591760
Blood. 2006 Feb 15;107(4):1491-6
pubmed: 16249389
Cancer Res. 1999 Apr 15;59(8):1954-60
pubmed: 10213506
Glycobiology. 2010 Nov;20(11):1373-9
pubmed: 20663960
J Exp Med. 1998 Aug 3;188(3):549-59
pubmed: 9687532
J Clin Invest. 2013 Sep;123(9):3889-901
pubmed: 23945237
Blood. 2008 Dec 15;112(13):5046-51
pubmed: 18784372
Blood. 2008 Apr 15;111(8):4165-72
pubmed: 18073347
J Exp Med. 2001 Aug 6;194(3):235-46
pubmed: 11489943
J Biol Chem. 2003 Jan 31;278(5):3372-7
pubmed: 12438315
J Exp Med. 1994 Aug 1;180(2):687-92
pubmed: 8046342
J Immunol. 1989 Dec 1;143(11):3853-7
pubmed: 2479694
Cancer Immunol Res. 2019 Jul;7(7):1162-1174
pubmed: 31088844
Nature. 2002 Oct 17;419(6908):734-8
pubmed: 12384702
Cancer Biol Ther. 2016 Dec;17(12):1253-1265
pubmed: 27834580
Curr Biol. 1998 May 7;8(10):545-53
pubmed: 9601638
Blood. 2006 Jan 1;107(1):159-66
pubmed: 16150947
Blood. 2005 Jul 15;106(2):577-83
pubmed: 15817676
Cancers (Basel). 2019 Jun 03;11(6):
pubmed: 31163679
J Immunol. 2006 Aug 15;177(4):2349-55
pubmed: 16887996
J Exp Med. 2000 Sep 4;192(5):613-24
pubmed: 10974028
Nature. 1998 Feb 12;391(6668):703-7
pubmed: 9490415
Immunol Rev. 2006 Dec;214:73-91
pubmed: 17100877
Immunity. 2001 Feb;14(2):123-33
pubmed: 11239445
Blood. 2012 Mar 29;119(13):3064-72
pubmed: 22323453
J Biol Chem. 1998 Oct 16;273(42):27518-23
pubmed: 9765283
J Exp Med. 2008 Dec 22;205(13):2959-64
pubmed: 19029379
J Exp Med. 1997 Dec 1;186(11):1809-18
pubmed: 9382880
Oncoimmunology. 2017 Aug 21;6(9):e1339854
pubmed: 28932639
J Pathol. 2002 Mar;196(3):266-74
pubmed: 11857488
Eur J Immunol. 2004 Jun;34(6):1673-9
pubmed: 15162437
Front Immunol. 2014 Apr 02;5:145
pubmed: 24765094
J Immunol. 2004 Aug 15;173(4):2470-8
pubmed: 15294961
Eur J Immunol. 2019 Jan;49(1):54-65
pubmed: 30512185
J Clin Oncol. 2012 Jun 1;30(16):1953-9
pubmed: 22547589
J Immunol. 2013 Aug 15;191(4):1883-94
pubmed: 23851692
Clin Cancer Res. 2019 Oct 15;25(20):6052-6060
pubmed: 31308062
Nature. 2014 Mar 27;507(7493):508-12
pubmed: 24553136
Blood. 2005 Jun 15;105(12):4722-9
pubmed: 15713798
Scand J Immunol. 2002 Mar;55(3):233-7
pubmed: 11940229
Nature. 1989 Dec 14;342(6251):803-5
pubmed: 2532305
J Immunol. 1997 Dec 1;159(11):5192-6
pubmed: 9548455
Immunogenetics. 2001 Sep;53(7):572-83
pubmed: 11685470
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9397-401
pubmed: 7568140
Blood. 2009 Mar 12;113(11):2470-7
pubmed: 18840707
Nat Immunol. 2002 Dec;3(12):1142-9
pubmed: 12426565
J Immunol. 2002 Apr 1;168(7):3351-9
pubmed: 11907092
J Immunol. 2012 Aug 1;189(3):1360-71
pubmed: 22730533
Nat Immunol. 2009 Jan;10(1):48-57
pubmed: 19011627
Clin Cancer Res. 2016 Nov 1;22(21):5183-5188
pubmed: 27620276
Nat Commun. 2014 Aug 14;5:4539
pubmed: 25119382
BMC Cancer. 2004 Oct 07;4:73
pubmed: 15471548
Glycobiology. 2005 Jul;15(7):667-76
pubmed: 15703304
Immunity. 1996 Jan;4(1):67-76
pubmed: 8574853
J Immunol. 1998 Dec 1;161(11):5809-12
pubmed: 9834056
Annu Rev Immunol. 2015;33:355-91
pubmed: 25594431
Cell Death Differ. 2013 Mar;20(3):456-64
pubmed: 23154388
Nat Immunol. 2000 Aug;1(2):119-26
pubmed: 11248803
J Clin Invest. 2009 May;119(5):1251-63
pubmed: 19349689
J Biol Chem. 2006 Feb 3;281(5):2430-40
pubmed: 16267043
J Immunol. 1999 Nov 1;163(9):4651-4
pubmed: 10528161
J Immunol. 1990 Oct 1;145(7):2353-8
pubmed: 1975828
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10410-10415
pubmed: 30254166
Nat Immunol. 2006 Jul;7(7):747-54
pubmed: 16751775
N Engl J Med. 2020 Feb 6;382(6):545-553
pubmed: 32023374
Nat Immunol. 2003 Jun;4(6):565-72
pubmed: 12740576
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3017-22
pubmed: 18287025
J Exp Med. 1997 Feb 17;185(4):795-800
pubmed: 9034158
J Immunol. 2001 Apr 15;166(8):5034-43
pubmed: 11290784
Nat Immunol. 2012 Dec;13(12):1171-7
pubmed: 23142773
Front Immunol. 2013 Mar 27;4:76
pubmed: 23543707
Immunity. 2018 Jan 16;48(1):107-119.e4
pubmed: 29329948
Cell. 2010 Sep 17;142(6):847-56
pubmed: 20850008
Crit Rev Oncog. 2014;19(1-2):1-13
pubmed: 24941370
Sci Rep. 2014 May 30;4:5088
pubmed: 24875800
Oncoimmunology. 2016 Apr 25;6(1):e1137418
pubmed: 28197361
Hum Vaccin Immunother. 2014;10(7):2123-9
pubmed: 25424829
J Exp Med. 1996 Dec 1;184(6):2243-50
pubmed: 8976179
J Immunol. 2004 May 1;172(9):5535-43
pubmed: 15100296
Cancer. 2000 Feb 1;88(3):577-83
pubmed: 10649250
J Exp Med. 1993 Aug 1;178(2):597-604
pubmed: 8340759
J Virol. 2015 Oct;89(19):9909-19
pubmed: 26202228
J Immunol. 2000 Aug 1;165(3):1314-21
pubmed: 10903732
Oncotarget. 2018 Apr 3;9(25):17675-17688
pubmed: 29707140
Eur J Immunol. 1998 Nov;28(11):3423-34
pubmed: 9842885
Nat Immunol. 2002 Dec;3(12):1150-5
pubmed: 12426564
Anticancer Res. 2015 Apr;35(4):2287-97
pubmed: 25862891
J Exp Med. 2015 Nov 16;212(12):2165-82
pubmed: 26552706
Immunol Cell Biol. 2014 Mar;92(3):221-9
pubmed: 24366519
Front Immunol. 2017 Apr 10;8:387
pubmed: 28443091
Blood Cancer J. 2019 Jan 15;9(2):6
pubmed: 30647406
PLoS Genet. 2005 Aug;1(2):129-39
pubmed: 16132082
Mod Pathol. 2012 Jan;25(1):36-45
pubmed: 21909078
Bone Marrow Transplant. 2019 Aug;54(Suppl 2):785-788
pubmed: 31431708
Biochem Biophys Res Commun. 2006 Dec 15;351(2):571-6
pubmed: 17069754
Cancer Immunol Immunother. 2013 Dec;62(12):1841-9
pubmed: 24162108
Blood. 2017 Jun 29;129(26):3407-3418
pubmed: 28465343
J Biol Chem. 2016 Sep 2;291(36):18740-52
pubmed: 27385590
PLoS One. 2007 Dec 19;2(12):e1339
pubmed: 18092004
J Immunol. 2001 Nov 15;167(10):5517-21
pubmed: 11698418
J Cell Biol. 2006 Jul 3;174(1):153-61
pubmed: 16801390
J Immunol. 1996 Dec 1;157(11):4741-5
pubmed: 8943374
Blood. 2013 May 2;121(18):3599-608
pubmed: 23487023
J Cell Biol. 2009 Nov 16;187(4):569-81
pubmed: 19948503
Immunity. 2012 Apr 20;36(4):600-11
pubmed: 22464172
Science. 1999 Jul 30;285(5428):727-9
pubmed: 10426993
Clin Immunol. 2009 Nov;133(2):171-8
pubmed: 19481979
PLoS One. 2007 Mar 28;2(3):e326
pubmed: 17389917
Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6259-63
pubmed: 8022771
J Exp Med. 2014 Apr 7;211(4):727-42
pubmed: 24687958
Front Immunol. 2018 May 17;9:1072
pubmed: 29868026
Int Immunol. 2001 Apr;13(4):459-63
pubmed: 11282985
Immunol Lett. 2017 Sep;189:40-47
pubmed: 28414184
Proc Natl Acad Sci U S A. 2008 May 6;105(18):6696-701
pubmed: 18448674
Front Immunol. 2015 Sep 25;6:495
pubmed: 26441997
Immunity. 1999 Nov;11(5):615-23
pubmed: 10591186
J Exp Med. 1995 Jun 1;181(6):1953-6
pubmed: 7539033
Nat Immunol. 2018 Jul;19(7):723-732
pubmed: 29915296
J Biol Chem. 2004 Apr 30;279(18):18662-9
pubmed: 14988414
Eur Respir J. 2008 Sep;32(3):563-70
pubmed: 18417514
Structure. 2003 Jun;11(6):725-34
pubmed: 12791260
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13765-70
pubmed: 9811875
J Immunol. 2006 Nov 1;177(9):5759-60
pubmed: 17056497
Clin Cancer Res. 2009 Nov 15;15(22):6993-7002
pubmed: 19861434
Lancet Oncol. 2018 Jan;19(1):40-50
pubmed: 29233559
Immunity. 1996 Jan;4(1):77-85
pubmed: 8574854
Front Microbiol. 2012 Dec 31;3:429
pubmed: 23293633
Crit Rev Oncog. 2014;19(1-2):91-105
pubmed: 24941376
Neoplasia. 2017 Jun;19(6):471-482
pubmed: 28499126
Immunity. 2012 Jun 29;36(6):974-85
pubmed: 22683124
Cancer Res. 2004 Dec 15;64(24):9180-4
pubmed: 15604290
Cancer Immunol Immunother. 2009 Sep;58(9):1517-26
pubmed: 19259667
Immunity. 2010 Feb 26;32(2):175-86
pubmed: 20189481
J Immunol. 2006 Sep 1;177(5):3170-7
pubmed: 16920955
J Biol Chem. 1999 Nov 26;274(48):34089-95
pubmed: 10567377
J Exp Med. 1994 Mar 1;179(3):1011-5
pubmed: 8113669
Front Immunol. 2018 Feb 02;9:150
pubmed: 29456538
Immunity. 2009 Jul 17;31(1):35-46
pubmed: 19604491
Eur J Immunol. 1997 Feb;27(2):563-7
pubmed: 9045931
J Exp Med. 1998 Jun 15;187(12):2065-72
pubmed: 9625766
J Immunol. 1999 Apr 15;162(8):4745-54
pubmed: 10202016
Immunol Cell Biol. 2005 Feb;83(1):1-8
pubmed: 15661035
Blood. 2010 Mar 18;115(11):2167-76
pubmed: 19965656
Immunogenetics. 2003 Jul;55(4):220-6
pubmed: 12838378
J Immunol. 2012 Jun 15;188(12):6165-74
pubmed: 22615207
Cell. 1995 Feb 24;80(4):661-70
pubmed: 7867073
Glycobiology. 2011 Sep;21(9):1121-4
pubmed: 21932452
Immunity. 1996 Dec;5(6):629-38
pubmed: 8986721
J Immunol. 1993 Jul 1;151(1):60-70
pubmed: 8326140
Int J Mol Med. 1998 Sep;2(3):349-51
pubmed: 9855710
J Immunol. 2000 Aug 1;165(3):1197-209
pubmed: 10903717
Immunity. 2006 Aug;25(2):331-42
pubmed: 16901727
Clin Cancer Res. 2009 Aug 1;15(15):4857-66
pubmed: 19638467
Immunity. 1997 Aug;7(2):273-82
pubmed: 9285411
Front Immunol. 2018 Sep 27;9:2164
pubmed: 30319626
J Exp Med. 1992 Dec 1;176(6):1751-5
pubmed: 1281218
J Immunol Methods. 2009 Aug 31;348(1-2):9-17
pubmed: 19552894
Immunology. 2011 Mar;132(3):315-25
pubmed: 21214544
J Clin Oncol. 2006 May 1;24(13):1997-2005
pubmed: 16648500
Nat Immunol. 2012 Sep;13(9):832-42
pubmed: 22842346
Oncotarget. 2012 Aug;3(8):882-92
pubmed: 22929570
Immunity. 2016 May 17;44(5):989-1004
pubmed: 27192565
Eur J Immunol. 2003 Jun;33(6):1642-8
pubmed: 12778482
J Immunol. 2007 Apr 15;178(8):4764-70
pubmed: 17404256
Nat Immunol. 2008 Aug;9(8):898-907
pubmed: 18604210
Nat Immunol. 2006 May;7(5):524-32
pubmed: 16582911
Nat Genet. 1998 Oct;20(2):129-35
pubmed: 9771704
J Biol Chem. 2000 Jul 21;275(29):22121-6
pubmed: 10801862
Nat Rev Immunol. 2020 Mar;20(3):173-185
pubmed: 31676858
Semin Cancer Biol. 2002 Feb;12(1):57-61
pubmed: 11926413
Scand J Immunol. 2017 Sep;86(3):135-142
pubmed: 28605050
J Immunol. 2004 May 1;172(9):5450-5
pubmed: 15100286
J Immunol. 2010 Feb 15;184(4):1918-30
pubmed: 20083673
Curr Protoc Immunol. 2010 Aug;Chapter 11:Unit 11.9B
pubmed: 20814939
Nat Med. 1999 Dec;5(12):1365-9
pubmed: 10581077
Nat Immunol. 2003 Jan;4(1):19-24
pubmed: 12496974
Immunol Rev. 1997 Feb;155:67-77
pubmed: 9059883
Front Immunol. 2018 Jun 18;9:1324
pubmed: 29973929
Immunobiology. 2019 May;224(3):362-370
pubmed: 30876792
J Allergy Clin Immunol. 2017 Jan;139(1):335-346.e3
pubmed: 27372564
Nat Rev Immunol. 2005 Mar;5(3):201-14
pubmed: 15719024
Gut. 2001 Aug;49(2):236-40
pubmed: 11454801
Cell. 1993 Mar 12;72(5):767-78
pubmed: 7680959
Oncoimmunology. 2014 Jan 1;3(1):e27988
pubmed: 24800176
Immunity. 1997 Aug;7(2):283-90
pubmed: 9285412
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14151-6
pubmed: 14612578
J Immunol. 1999 Jun 15;162(12):6981-5
pubmed: 10358138
Biochemistry. 1995 Oct 17;34(41):13320-7
pubmed: 7577916
Cancer Cell. 2017 Aug 14;32(2):135-154
pubmed: 28810142
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3837-41
pubmed: 1827205
J Clin Invest. 2020 May 11;:
pubmed: 32134744
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2274-8
pubmed: 2138330
Clin Cancer Res. 2014 Jul 1;20(13):3390-400
pubmed: 24987108
Science. 1996 Apr 19;272(5260):405-8
pubmed: 8602528
Annu Rev Immunol. 2001;19:197-223
pubmed: 11244035
Front Immunol. 2019 Jan 28;10:24
pubmed: 30745901
Cell Mol Immunol. 2017 Apr;14(4):321-330
pubmed: 27264685
Tissue Antigens. 2004 Sep;64(3):215-25
pubmed: 15304001
J Clin Invest. 2015 May;125(5):2077-89
pubmed: 25893601
J Immunol. 2010 Jan 15;184(2):902-11
pubmed: 20008292
Nat Immunol. 2001 May;2(5):436-42
pubmed: 11323698
J Cell Biol. 2016 Dec 19;215(6):875-889
pubmed: 27903610
Genes Immun. 2000 Dec;1(8):504-8
pubmed: 11197693
J Exp Med. 1997 Feb 17;185(4):673-84
pubmed: 9034146
Nat Immunol. 2001 Mar;2(3):261-8
pubmed: 11224527
J Exp Med. 2006 Jun 12;203(6):1419-25
pubmed: 16754721
J Immunol. 2010 Oct 15;185(8):4698-704
pubmed: 20833835
J Exp Med. 2008 Dec 22;205(13):2965-73
pubmed: 19029380
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3384-9
pubmed: 17360655
J Clin Oncol. 2012 Jun 1;30(16):1960-5
pubmed: 22291084
J Exp Med. 1989 Aug 1;170(2):481-97
pubmed: 2526846
Immunol Lett. 1998 Apr;61(2-3):109-12
pubmed: 9657262
Immunity. 2004 Sep;21(3):367-77
pubmed: 15357948
J Immunol. 2007 Feb 1;178(3):1277-84
pubmed: 17237373
Eur J Immunol. 1998 Dec;28(12):4409-17
pubmed: 9862378
Immunol Rev. 2007 Dec;220:169-82
pubmed: 17979846
J Exp Med. 1997 Oct 6;186(7):1129-36
pubmed: 9314561
Int J Cancer. 1972 May 15;9(3):648-58
pubmed: 4513057
Immunol Cell Biol. 2014 Mar;92(3):237-44
pubmed: 24343663
Nat Med. 2011 Jun;17(6):700-7
pubmed: 21552268
Nat Immunol. 2009 Sep;10(9):973-80
pubmed: 19648922
J Exp Med. 2005 Jan 17;201(2):211-20
pubmed: 15642742
J Immunol. 2002 Apr 1;168(7):3155-64
pubmed: 11907067
Am J Cancer Res. 2019 May 01;9(5):945-958
pubmed: 31218103
Front Immunol. 2019 Oct 10;10:2361
pubmed: 31649672
Nat Immunol. 2014 May;15(5):431-8
pubmed: 24658051
PLoS One. 2009 Jun 25;4(6):e6046
pubmed: 19557128
Cell Mol Immunol. 2019 Nov;16(11):868-877
pubmed: 30275537
J Cell Biol. 2018 Sep 3;217(9):3267-3283
pubmed: 29967280
J Biol Chem. 2018 Oct 19;293(42):16348-16363
pubmed: 30190323
Open Biol. 2016 May;6(5):
pubmed: 27249817
J Exp Med. 2011 Dec 19;208(13):2633-40
pubmed: 22143889
Eur J Immunol. 1999 Sep;29(9):2748-58
pubmed: 10508249
J Biol Chem. 2003 Nov 14;278(46):46081-6
pubmed: 12960161
Blood. 2012 Nov 22;120(22):4317-23
pubmed: 23002117
J Exp Med. 1999 Nov 15;190(10):1505-16
pubmed: 10562324
Immunol Rev. 2015 Sep;267(1):88-116
pubmed: 26284473
Proc Natl Acad Sci U S A. 1989 Apr;86(7):2361-4
pubmed: 2784569
Eur J Immunol. 1999 Jan;29(1):277-83
pubmed: 9933109
Trends Immunol. 2018 Mar;39(3):222-239
pubmed: 29397297
Proc Natl Acad Sci U S A. 1962 Jul 15;48:1172-7
pubmed: 13897149
J Immunol. 2006 Nov 1;177(9):5761-5
pubmed: 17056498
J Exp Med. 2000 Oct 2;192(7):1059-68
pubmed: 11015446
Science. 2015 Apr 3;348(6230):56-61
pubmed: 25838373
Science. 1996 May 24;272(5265):1173-6
pubmed: 8638162
Nat Med. 2001 Jan;7(1):94-100
pubmed: 11135622
J Immunol. 2000 Oct 1;165(7):3545-8
pubmed: 11034353
Science. 1989 Dec 22;246(4937):1608-11
pubmed: 2531918
J Immunol. 2002 Aug 15;169(4):1948-58
pubmed: 12165520