Hemodynamic Profiles and Their Prognostic Relevance in Cardiac Amyloidosis.
cardiac amyloidosis
invasive hemodynamics
outcomes
pulmonary arterial pressures
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
11 Apr 2020
11 Apr 2020
Historique:
received:
11
03
2020
revised:
03
04
2020
accepted:
07
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
This study sought to characterize cardiac amyloidosis (CA) patients with respect to hemodynamic parameters and asses their prognostic impact in different CA cohorts. Intracardiac and pulmonary arterial pressures (PAPs) are among the strongest predictors of outcomes in patients with heart failure (HF). Despite that, the hemodynamic profiles of patients with CA and their relation to prognosis have rarely been investigated. Invasive hemodynamic, clinical, and laboratory assessment, as well as cardiac magnetic resonance imaging were performed in our CA cohort. A total of 61 patients, 35 (57.4%) with wild-type transthyretin amyloidosis (ATTRwt) and 26 (42.6%) with light-chain amyloidosis (AL) were enrolled. ATTRwt patients had lower N-terminal prohormone of brain natriuretic peptide values and were less frequently in New York Heart Association class ≥ III. Intracardiac and PAPs were elevated, but hemodynamic parameters did not differ between CA groups. Whereas in ATTRwt, the median mean PAP (hazard ratio (HR): 1.130,
Identifiants
pubmed: 32290508
pii: jcm9041093
doi: 10.3390/jcm9041093
pmc: PMC7230541
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical Scientific Fund of the Mayor of the City of Vienna
ID : 19011
Organisme : Austrian Society of Cardiology
ID : AP00778OFF
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