HCV Interplay with Lipoproteins: Inside or Outside the Cells?
cell entry
hepatitis C virus
immune escape
lipidation
lipoproteins
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
12 04 2020
12 04 2020
Historique:
received:
25
03
2020
revised:
05
04
2020
accepted:
10
04
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Hepatitis C virus (HCV) infection is a major public health issue leading to chronic liver diseases. HCV particles are unique owing to their particular lipid composition, namely the incorporation of neutral lipids and apolipoproteins. The mechanism of association between HCV virion components and these lipoproteins factors remains poorly understood as well as its impact in subsequent steps of the viral life cycle, such as entry into cells. It was proposed that the lipoprotein biogenesis pathway is involved in HCV morphogenesis; yet, recent evidence indicated that HCV particles can mature and evolve biochemically in the extracellular medium after egress. In addition, several viral, cellular and blood components have been shown to influence and regulate this specific association. Finally, this specific structure and composition of HCV particles was found to influence entry into cells as well as their stability and sensitivity to neutralizing antibodies. Due to its specific particle composition, studying the association of HCV particles with lipoproteins remains an important goal towards the rational design of a protective vaccine.
Identifiants
pubmed: 32290553
pii: v12040434
doi: 10.3390/v12040434
pmc: PMC7232430
pii:
doi:
Substances chimiques
Lipoproteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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