Continuous Positive Airway Pressure Treatment, Glycemia, and Diabetes Risk in Obstructive Sleep Apnea and Comorbid Cardiovascular Disease.


Journal

Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975

Informations de publication

Date de publication:
08 2020
Historique:
received: 08 10 2019
accepted: 15 03 2020
pubmed: 16 4 2020
medline: 6 3 2021
entrez: 16 4 2020
Statut: ppublish

Résumé

Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of long-term continuous positive airway pressure (CPAP) treatment on glycemic control and diabetes risk in patients with cardiovascular disease (CVD) and OSA. Blood, medical history, and personal data were collected in a substudy of 888 participants in the Sleep Apnea cardioVascular Endpoints (SAVE) trial in which patients with OSA and stable CVD were randomized to receive CPAP plus usual care, or usual care alone. Serum glucose and glycated hemoglobin A Median follow-up was 4.3 years. In those with preexisting diabetes ( Among patients with established CVD and OSA, we found no evidence that CPAP therapy over several years affects glycemic control in those with diabetes or prediabetes or diabetes risk over standard-of-care treatment. The potential differential effect according to sex deserves further investigation.

Identifiants

pubmed: 32291275
pii: dc19-2006
doi: 10.2337/dc19-2006
doi:

Substances chimiques

Blood Glucose 0
Glycated Hemoglobin A 0
hemoglobin A1c protein, human 0

Banques de données

ClinicalTrials.gov
['NCT00738179']
ANZCTR
['ACTRN12608000409370']

Types de publication

Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1859-1867

Investigateurs

Maree Barnes (M)
Fengchun Yu (F)
Xiaomei Meng (X)
Wei Liu (W)
Xinping Chen (X)
Xiaomei Tang (X)
Gaohui Xiao (G)
Maolin He (M)
Jingjing Liu (J)
Matt Naughton (M)
Michelle Hooy (M)
Sophie Yorkston (S)
Michael Hlavac (M)
Michael James Epton (MJ)
Malina Kate Storer (MK)
Julie Margaret Cook (JM)
Alastair Corbett (A)
Rosie Portley (R)
Ben Brockway (B)
Jan Cowan (J)
D Robin Taylor (DR)
Emma Cox (E)
Rochelle Palmay (R)
Alan Young (A)
Sue Del Sasso (SD)
Irina Shinkarksy (I)
Ilana Shinkarksy (I)
Francis Thien (F)
Denise O'Driscoll (D)
Angela Anniss (A)
Wei Wang (W)
Hui Shen (H)
Derek Chew (D)
Frances Kissajukian (F)
Kate Luscombe (K)
Fiona Wollaston (F)
Zhihong Liu (Z)
Qiong Ou (Q)
Baoliang Du (B)
Yanxia Wang (Y)
Yanhua Guo (Y)
Wei Dong (W)
Lixin Wu (L)
Kunlun Yu (K)
Shengli Wang (S)
Junyan Shi (J)
Luciano Drager (L)
Gabriela A Souza (GA)
Daniel B C Queiróz (DBC)
Katherine Ferrier (K)
Judy Dewar (J)
Ria Kleintjes (R)
Jo Kovacs (J)
Angela Campbell (A)
Alister Neill (A)
Yuechun Li (Y)
Xiue Li (X)
Ruichun Pan (R)
Hui Xue (H)
Celso Amodeo (C)
Juliana Silva (J)
Renata Depizzol (R)
Dalete de Andrade (D)
Adriana Bertolami (A)
Carolina Gonzaga (C)
Geraldo Lorenzi-Filho (G)
Gabriela A Souza (GA)
Daniel B C Queiróz (DBC)
Lia Bittencourt (L)
Carolina Ferreira (C)
Madga Bignotto (M)
Zhiqing Pan (Z)
Yu Dou (Y)
Meiyu Zhu (M)
Gan Lu (G)
Margaret Arstall (M)
William Jeffries (W)
Naomi Lamberts (N)
Garun Hamilton (G)
Joanne McKenzie (J)
Xiuwei Zhang (X)
Yi Xiao (Y)
Rong Huang (R)
Doug McEvoy (D)
Nick Antic (N)
Denzil Paul (D)
Amanda McKenna (A)
Craig Anderson (C)
Candice Delcourt (C)
Cheryl Carcel (C)
Elizabeth Ray (E)
Theodora Paraskevaidis (T)
Sabrina Small (S)
Huili Zhu (H)
Yulu Liang (Y)
Min Li (M)
Xinbing Liu (X)
Minpeng Wang (M)
Jiangtao Lin (J)
YiMing Li (Y)
Neil Graham (N)
Mary Elizabeth Molloy (ME)
Li'e Wu (L)
Xia Guo (X)
Junping Wu (J)
Zhendong Li (Z)
Xiaohua Xu (X)
Yuangming Luo (Y)
Zhihui Qiu (Z)
Xilong Zhang (X)
Chong Li (C)
Wanda Peng (W)
Guocui Zhen (G)
Jian Hong Liu (JH)
James Douglas (J)
Nicola Dunn (N)
Darren Walters (D)
Ling Lan (L)
Jane Mikli (J)
Andrew Wong (A)
Deanne Curtin (D)
Jan Robinson (J)
Liwen Tai (L)
Huijuan Wang (H)
Rui Chen (R)
Yanqiu Sun (Y)
Yanyu He (Y)
Bei Wang (B)
Zhuda Liu (Z)
Hui Zhao (H)
Xiaoling Gao (X)
Yanfeng Fan (Y)
Hanqiao Wang (H)
Cat Chang (C)
Christine Tuffery (C)
Sandra Hopping (S)
Nigel McArdle (N)
Sutapa Mukherjee (S)
Bernadett Boeing (B)
David Hillman (D)
Siobhan Clare Rea (SC)
Xuejun Guo (X)
Lianping Ren (L)
Jinyuan Sun (J)
Yiping Sun (Y)
Guangyue Qin (G)
Shanqun Li (S)
Wenjing Li (W)
Xiaodan Wu (X)
Jing Zhou (J)
Hong Jiang (H)
Laura Bandick (L)
Michaela O'Keefe (M)
Jeremy Mercer (J)
Mark Jurisevic (M)
Samantha Mead (S)
Emma Heeley (E)
Ruth Freed (R)
Tina Cheung (T)
Natalie Espinosa (N)
Sarah Leighton (S)
Tara Sasse (T)
Michelle Leroux (M)
Shu Ying (S)
Yuehan Zheng (Y)
Wei Wei (W)
Hongyu Zhang (H)
Jing Zhou (J)
Haijing Jia (H)
Meng Zhang (M)
Buliang Cui (B)
Hua Deng (H)
Aiwu Song (A)
Doug McEvoy (D)
Craig Anderson (C)
Ron Grunstein (R)
Jan Hedner (J)
Shaoguang Huang (S)
Geraldo Lorenzi-Filho (G)
Bruce Neal (B)
Lyle Palmer (L)
Susan Redline (S)
Jiguang Wang (J)
Nanshan Zhong (N)

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2020 by the American Diabetes Association.

Auteurs

Kelly A Loffler (KA)

Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia kelly.loffler@flinders.edu.au doug.mcevoy@flinders.edu.au.

Emma Heeley (E)

Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Ruth Freed (R)

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.

Rosie Meng (R)

Flinders Centre for Epidemiology and Biostatistics, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

Lia R Bittencourt (LR)

Instituto do Sono, Associação Fundo de Incentivo a Pesquisa, São Paulo, Brazil.

Carolina C Gonzaga Carvalho (CC)

Sleep Laboratory, Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.

Rui Chen (R)

The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Michael Hlavac (M)

Christchurch Hospital, Christchurch, New Zealand.

Zhihong Liu (Z)

Fuwai Hospital, Beijing, China.

Geraldo Lorenzi-Filho (G)

Sleep Laboratory, Pulmonary Division, Instituto do Coração, University of São Paulo, São Paulo, Brazil.

Yuanming Luo (Y)

The First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong, China.

Nigel McArdle (N)

West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

Sutapa Mukherjee (S)

Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
West Australian Sleep Disorders Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network, Bedford Park, South Australia, Australia.

Hooi Shan Yap (HS)

Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network, Bedford Park, South Australia, Australia.

Xilong Zhang (X)

The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Lyle J Palmer (LJ)

School of Public Health, University of Adelaide, Adelaide, South Australia, Australia.

Craig S Anderson (CS)

The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
The George Institute for Global Health China at Peking University Health Science Center, Beijing, China.

R Doug McEvoy (RD)

Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia kelly.loffler@flinders.edu.au doug.mcevoy@flinders.edu.au.
Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network, Bedford Park, South Australia, Australia.

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Classifications MeSH