Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
13
03
2019
accepted:
03
04
2020
pubmed:
16
4
2020
medline:
31
12
2020
entrez:
16
4
2020
Statut:
ppublish
Résumé
Insulin is first produced in pancreatic β-cells as the precursor prohormone proinsulin. Defective proinsulin processing has been implicated in the pathogenesis of both type 1 and type 2 diabetes. Though there is substantial evidence that mouse β-cells process proinsulin using prohormone convertase 1/3 (PC1/3) and then prohormone convertase 2 (PC2), this finding has not been verified in human β-cells. Immunofluorescence with validated antibodies revealed that there was no detectable PC2 immunoreactivity in human β-cells and little
Identifiants
pubmed: 32291281
pii: db19-0276
doi: 10.2337/db19-0276
doi:
Substances chimiques
Proinsulin
9035-68-1
Proprotein Convertase 1
EC 3.4.21.93
PCSK2 protein, human
EC 3.4.21.94
Proprotein Convertase 2
EC 3.4.21.94
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1451-1462Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2020 by the American Diabetes Association.