Protein Kinase C-
Animals
Apoptosis
Cell Division
Cells, Cultured
Cold Temperature
/ adverse effects
Dynamins
/ metabolism
Enzyme Activation
Kidney Transplantation
Kidney Tubular Necrosis, Acute
/ enzymology
Kidney Tubules, Proximal
/ enzymology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ enzymology
Organ Preservation
/ methods
Phosphorylation
Protein Kinase C-delta
/ antagonists & inhibitors
Protein Kinase Inhibitors
/ pharmacology
Protein Processing, Post-Translational
Rats
PKCδ; kidney
ischemia-reperfusion
mitochondria
transplantation
Journal
Journal of the American Society of Nephrology : JASN
ISSN: 1533-3450
Titre abrégé: J Am Soc Nephrol
Pays: United States
ID NLM: 9013836
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
15
10
2019
accepted:
24
02
2020
pubmed:
16
4
2020
medline:
29
12
2020
entrez:
16
4
2020
Statut:
ppublish
Résumé
Kidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C- To investigate PKC We observed PKC These results indicate that PKC
Sections du résumé
BACKGROUND
Kidney injury associated with cold storage is a determinant of delayed graft function and the long-term outcome of transplanted kidneys, but the underlying mechanism remains elusive. We previously reported a role of protein kinase C-
METHODS
To investigate PKC
RESULTS
We observed PKC
CONCLUSIONS
These results indicate that PKC
Identifiants
pubmed: 32291286
pii: ASN.2019101060
doi: 10.1681/ASN.2019101060
pmc: PMC7217420
doi:
Substances chimiques
Protein Kinase Inhibitors
0
Prkcd protein, mouse
EC 2.7.1.-
Protein Kinase C-delta
EC 2.7.11.13
Dnm1l protein, mouse
EC 3.6.5.5
Dynamins
EC 3.6.5.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1050-1065Subventions
Organisme : BLRD VA
ID : I01 BX000319
Pays : United States
Organisme : BLRD VA
ID : IK6 BX005236
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK058831
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK087843
Pays : United States
Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
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