Alterations of Brain Signal Oscillations in Older Individuals with HIV Infection and Parkinson's Disease.
Age
Amplitudes of low frequency fluctuations (ALFF)
HIV infection
Parkinson’s disease
Resting-state fMRI
Journal
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
ISSN: 1557-1904
Titre abrégé: J Neuroimmune Pharmacol
Pays: United States
ID NLM: 101256586
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
09
01
2020
accepted:
09
03
2020
pubmed:
16
4
2020
medline:
15
12
2021
entrez:
16
4
2020
Statut:
ppublish
Résumé
More than 30 years after the human immunodeficiency virus (HIV) epidemic, HIV patients are now aging due to the advances of antiretroviral therapy. With immunosenescence and the susceptibility of dopamine-rich basal ganglia regions to HIV-related injury, older HIV patients may show neurofunctional deficits similar to patients with Parkinson's disease (PD). We examined the amplitudes of low frequency fluctuations (ALFF) across different frequency bands of the BOLD signal in 30 older HIV-infected individuals, 33 older healthy controls, and 36 PD patients. Participants underwent resting-state fMRI, neuropsychological testing, and a clinical motor exam. HIV patients mainly showed abnormalities in cortical ALFF with reduced prefrontal amplitudes and enhanced sensorimotor and inferior temporal amplitudes. Frontal hypoactivation was overlapping for HIV and PD groups and different from controls. PD patients further exhibited reduced pallidum amplitudes compared to the other groups. In the HIV group, lower pallidum amplitudes were associated with lower CD4
Identifiants
pubmed: 32291601
doi: 10.1007/s11481-020-09914-x
pii: 10.1007/s11481-020-09914-x
pmc: PMC7554056
mid: NIHMS1584899
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
289-305Subventions
Organisme : NIAAA NIH HHS
ID : U01 AA017347
Pays : United States
Organisme : NIAAA NIH HHS
ID : U24 AA021697
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA023165
Pays : United States
Organisme : NIAAA NIH HHS
ID : AA017168
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047366
Pays : United States
Organisme : Michael J. Fox Foundation for Parkinson's Research
ID : 99999
Organisme : NIAAA NIH HHS
ID : AA023165
Pays : United States
Organisme : NINDS NIH HHS
ID : NS075097
Pays : United States
Organisme : NIAAA NIH HHS
ID : AA017347
Pays : United States
Organisme : NIAAA NIH HHS
ID : K05 AA017168
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS075097
Pays : United States
Organisme : NIA NIH HHS
ID : AG047366
Pays : United States
Organisme : NIAAA NIH HHS
ID : AA023165
Pays : United States
Organisme : NIAAA NIH HHS
ID : AA017347
Pays : United States
Organisme : NIAAA NIH HHS
ID : AA017168
Pays : United States
Organisme : NIA NIH HHS
ID : AG047366
Pays : United States
Organisme : NINDS NIH HHS
ID : NS075097
Pays : United States
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