Scalable Total Syntheses and Structure-Activity Relationships of Haouamines A, B, and Their Derivatives as Stable Formate Salts.
Friedel-Crafts cyclization
haouamines
macrocyclization
structure-activity relationships
“anti-Wacker”-type cyclization
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
received:
10
04
2020
pubmed:
16
4
2020
medline:
16
4
2020
entrez:
16
4
2020
Statut:
ppublish
Résumé
Haouamines A, B, and their derivatives were synthesized via Suzuki-Miyaura coupling and three key cyclization reactions as follows: the newly developed palladium(0)-catalyzed arylative cyclization of phenylalanine-derived alkyne-aldehydes with 2-bromoarylboronic acid (an "anti-Wacker"-type cyclization); BF
Identifiants
pubmed: 32291830
doi: 10.1002/chem.202001756
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12528-12532Subventions
Organisme : Platform Project for Supporting Drug Discovery and Life Science Research from AMED
ID : JP19am0101095
Organisme : Platform Project for Supporting Drug Discovery and Life Science Research from AMED
ID : JP19am0101100
Organisme : The Research Foundation for Pharmaceutical Sciences
Organisme : SUNTRY FOUNDATION for LIFE SCIENCES
Organisme : JSPS KAKENHI
ID : 2459004
Informations de copyright
© 2020 Wiley-VCH GmbH.
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