Unravelling myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Gender-specific changes in the microRNA expression profiling in ME/CFS.
exercise
gender
immune function
inflammation
microRNAs
myalgic encephalomyelitis/chronic fatigue syndrome
peripheral blood mononuclear cell
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
10
12
2019
revised:
16
03
2020
accepted:
18
03
2020
pubmed:
16
4
2020
medline:
1
5
2021
entrez:
16
4
2020
Statut:
ppublish
Résumé
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by medically unexplained debilitating fatigue with suggested altered immunological state. Our study aimed to explore peripheral blood mononuclear cells (PBMCs) for microRNAs (miRNAs) expression in ME/CFS subjects under an exercise challenge. The findings highlight the immune response and inflammation links to differential miRNA expression in ME/CFS. The present study is particularly important in being the first to uncover the differences that exist in miRNA expression patterns in males and females with ME/CFS in response to exercise. This provides new evidence for the understanding of differential miRNA expression patterns and post-exertional malaise in ME/CFS. We also report miRNA expression pattern differences associating with the nutritional status in individuals with ME/CFS, highlighting the effect of subjects' metabolic state on molecular changes to be considered in clinical research within the NINDS/CDC ME/CFS Common Data Elements. The identification of gender-based miRNAs importantly provides new insights into gender-specific ME/CFS susceptibility and demands exploration of sex-suited ME/CFS therapeutics.
Identifiants
pubmed: 32291908
doi: 10.1111/jcmm.15260
pmc: PMC7214164
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5865-5877Subventions
Organisme : NINDS NIH HHS
ID : R01 NS090200
Pays : United States
Organisme : NIH HHS
ID : 5R01AR057853-04
Pays : United States
Organisme : NINDS NIH HHS
ID : 5R01NS090200-02
Pays : United States
Organisme : NINDS NIH HHS
ID : 1R15NS087604-01A1
Pays : United States
Organisme : NIAID NIH HHS
ID : 1R21AI124187-01
Pays : United States
Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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