Screening of copper and palladium-mediated reactions compatible with DNA-encoded chemical libraries.
CuAAC reaction
DNA-compatible reactions
DNA-encoded chemical libraries
Sonogashira coupling
Suzuki coupling
Journal
Helvetica chimica acta
ISSN: 0018-019X
Titre abrégé: Helv Chim Acta
Pays: Switzerland
ID NLM: 2985094R
Informations de publication
Date de publication:
15 Apr 2019
15 Apr 2019
Historique:
pubmed:
16
4
2020
medline:
16
4
2020
entrez:
16
4
2020
Statut:
epublish
Résumé
The construction of DNA-encoded chemical libraries (DECLs) crucially relies on the availability of chemical reactions, which are DNA-compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, we present our optimization and validation procedures for three copper and palladium-catalyzed reactions (Suzuki cross-coupling, Sonogashira cross-coupling and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC)), which have been successfully used by our group for the construction of large encoded libraries.
Identifiants
pubmed: 32292208
doi: 10.1002/hlca.201900033
pmc: PMC7156289
mid: EMS85568
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Swiss National Science Foundation
ID : 163479
Pays : Switzerland
Organisme : European Research Council
ID : 670603
Pays : International