The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence.
SNP
choline acetyltransferase gene
dependence
tobacco
waterpipe
Journal
Tobacco induced diseases
ISSN: 1617-9625
Titre abrégé: Tob Induc Dis
Pays: Greece
ID NLM: 101201591
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
11
2019
revised:
07
02
2020
accepted:
17
02
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
Waterpipe tobacco smoking (WS) is a popular form of tobacco use, globally. While the impact of genetic variations on smoking behavior has been well-investigated, few studies have examined this issue with regard to WS. In the current study, associations between choline acetyltransferase gene (ChAT) rs1917810 and rs7094248 polymorphisms and WS dependence were examined. Genotyping of rs1917810 and rs7094248 in 266 Jordanian waterpipe smokers was performed using RFLP-PCR. Dependence on WS was measured using the LWDS-10J scale. The frequency of rs1917810 G allele was 38.5% and that of the rs7094248 G allele was 40.8%. The rs1917810 was significantly associated with the WS dependence level (p<0.05). Carriers of the AA genotype of rs1917810 were more dependent on WS than those with GG genotype (p<0.05). However, no association between rs7094248 single-nucleotide polymorphism (SNP) and dependence on WS was observed (p>0.05). The rs1917810 in the ChAT gene might be associated with dependence on WS.
Identifiants
pubmed: 32292317
doi: 10.18332/tid/118233
pii: 27
pmc: PMC7152786
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27Informations de copyright
© 2020 Khabour O.F. et al.
Déclaration de conflit d'intérêts
The authors have each completed and submitted an ICMJE form for disclosure of potential conflicts of interest. The authors declare that they have no competing interests, financial or otherwise, related to the current work. T. Eissenberg reports grants from US FDA/NIH during the conduct of the study and personal fees from legal firms, outside the submitted work. In addition, T. Eissenberg has a patent issued for a device that measures the puffing behavior of electronic cigarette users.
Références
Int J Dev Neurosci. 2018 Jun;67:14-18
pubmed: 29555563
Tob Control. 2019 Mar;28(2):181-188
pubmed: 29807946
Front Cell Neurosci. 2018 Jul 10;12:169
pubmed: 30050410
Nicotine Tob Res. 2013 Oct;15(10):1782-6
pubmed: 23616231
Public Health Rep. 2016 Jan-Feb;131(1):76-85
pubmed: 26843673
Heliyon. 2019 Feb 15;5(2):e01234
pubmed: 30815604
Nicotine Tob Res. 2014 Jul;16(7):915-22
pubmed: 24571810
Hum Genet. 2010 Jun;127(6):691-8
pubmed: 20383528
Clin Lung Cancer. 2020 Mar;21(2):171-176
pubmed: 31402126
Genet Mol Res. 2015 Aug 14;14(3):9555-61
pubmed: 26345888
Oral Health Prev Dent. 2015;13(3):253-9
pubmed: 25197731
Addict Behav. 2017 Mar;66:41-47
pubmed: 27871044
Subst Use Misuse. 2019;54(14):2275-2283
pubmed: 31347433
Pharmacology. 2018;102(3-4):223-232
pubmed: 30099467
Psychol Health. 2017 Aug;32(8):1018-1036
pubmed: 28553727
Tob Control. 2019 May;28(3):254-260
pubmed: 29895703
Exp Ther Med. 2014 Oct;8(4):1340-1344
pubmed: 25187851
Eur J Hum Genet. 2018 Dec;26(12):1824-1831
pubmed: 30089821
Mol Psychiatry. 2018 Sep;23(9):1911-1919
pubmed: 28972577
Neuropsychopharmacology. 2010 May;35(6):1374-82
pubmed: 20147892
Psychopharmacology (Berl). 2016 May;233(10):1765-77
pubmed: 26728894
Eur Urol Focus. 2015 Aug;1(1):3-16
pubmed: 28723352
Cochrane Database Syst Rev. 2015 Jul 31;(7):CD005549
pubmed: 26228266
Am J Prev Med. 2009 Dec;37(6):518-23
pubmed: 19944918
Ann Glob Health. 2019 Jan 22;85(1):
pubmed: 30741510
PLoS One. 2018 Feb 9;13(2):e0192191
pubmed: 29425207
J Chem Neuroanat. 2011 Dec;42(4):225-35
pubmed: 21382474
Subst Use Misuse. 2019;54(3):514-524
pubmed: 30688142
Hum Genet. 2012 Jan 31;:
pubmed: 22290489
Drug Alcohol Depend. 2019 Jul 1;200:19-25
pubmed: 31071495
Am J Drug Alcohol Abuse. 2016 Sep;42(5):556-566
pubmed: 27428758
Int J Environ Res Public Health. 2014 Sep 01;11(9):9008-23
pubmed: 25257355