NF-κB Inhibitors Attenuate MCAO Induced Neurodegeneration and Oxidative Stress-A Reprofiling Approach.
MCAO stroke
atorvastatin
caeffic acid phenethyl ester
cephalexin
mycophenolate
p-NF-κB
reprofiling
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
08
2019
accepted:
12
02
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
16
4
2020
Statut:
epublish
Résumé
Stroke is the leading cause of morbidity and mortality worldwide. About 87% of stroke cases are ischemic, which disrupt the physiological activity of the brain, thus leading to a series of complex pathophysiological events. Despite decades of research on neuroprotectants to probe for suitable therapies against ischemic stroke, no successful results have been obtained, and new alternative approaches are urgently required in order to combat this pathological torment. To address these problems, drug repositioning/reprofiling is explored extensively. Drug repurposing aims to identify new uses for already established drugs, and this makes it an attractive commercial strategy. Nuclear factor-kappa beta (NF-κB) is reported to be involved in many physiological and pathological conditions, such as neurodegeneration, neuroinflammation, and ischemia/reperfusion (I/R) injury. In this study, we examined the neuroprotective effects of atorvastatin, cephalexin, and mycophenolate against the NF-κB in ischemic stroke, as compared to the standard NF-κB inhibitor caeffic acid phenethyl ester (CAPE). An in-silico docking analysis was performed and their potential neuroprotective activities in the
Identifiants
pubmed: 32292329
doi: 10.3389/fnmol.2020.00033
pmc: PMC7121334
doi:
Types de publication
Journal Article
Retracted Publication
Langues
eng
Pagination
33Commentaires et corrections
Type : RetractionIn
Informations de copyright
Copyright © 2020 Ali, Shah, Zeb, Malik, Alvi, Alkury, Rashid, Hussain, Ullah, Ullah Khan, Koh and Li.
Références
Cancer Res. 2007 Nov 1;67(21):10475-83
pubmed: 17974991
Front Neurol. 2019 Nov 14;10:1178
pubmed: 31798514
Childs Nerv Syst. 2009 Dec;25(12):1555-61
pubmed: 19756653
Cold Spring Harb Perspect Biol. 2009 Oct;1(4):a000034
pubmed: 20066092
Fitoterapia. 2002 Nov;73 Suppl 1:S21-9
pubmed: 12495706
Food Chem Toxicol. 2009 Jul;47(7):1562-8
pubmed: 19361549
Restor Neurol Neurosci. 2004;22(2):73-9
pubmed: 15272142
J Vet Med Sci. 2014 Oct;76(10):1367-74
pubmed: 24998396
J Vet Med Sci. 2018 Apr 27;80(4):676-683
pubmed: 29563391
J Stroke Cerebrovasc Dis. 2018 Nov;27(11):3247-3255
pubmed: 30093197
J Basic Clin Physiol Pharmacol. 2014 May 1;25(2):131-7
pubmed: 24515999
Gene. 2013 Oct 10;528(2):84-92
pubmed: 23845784
Nucleic Acids Res. 2010 Nov;38(20):7179-86
pubmed: 20601405
Int J Stroke. 2012 Feb;7(2):150-6
pubmed: 22264368
J Cereb Blood Flow Metab. 2000 Mar;20(3):592-603
pubmed: 10724123
Bioinformatics. 2010 May 15;26(10):1374-5
pubmed: 20378556
Front Neurosci. 2014 Mar 04;8:44
pubmed: 24624056
Drug Des Devel Ther. 2019 Aug 02;13:2715-2727
pubmed: 31447548
Lab Anim Res. 2012 Jun;28(2):77-82
pubmed: 22787480
Redox Biol. 2019 Feb;21:101059
pubmed: 30576920
J Biol Chem. 2002 Jul 5;277(27):24694-700
pubmed: 11970948
Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):143-50
pubmed: 17662674
Biomed Res Int. 2014;2014:145342
pubmed: 24971312
J Pharmacol Toxicol Methods. 1998 Apr;39(3):155-62
pubmed: 9741390
Neurosci Lett. 2010 Mar 8;471(3):152-6
pubmed: 20100543
Front Pharmacol. 2019 Jun 26;10:663
pubmed: 31293416
NeuroRx. 2004 Jan;1(1):36-45
pubmed: 15717006
Neurotoxicology. 2019 May;72:38-50
pubmed: 30738807
Ther Adv Neurol Disord. 2018 Jul 30;11:1756286418789854
pubmed: 30083232
J Surg Res. 2016 Mar;201(1):141-8
pubmed: 26850195
J Neuroinflammation. 2018 Apr 21;15(1):119
pubmed: 29679979
J Postgrad Med. 2011 Apr-Jun;57(2):153-60
pubmed: 21654146
Eur J Pharmacol. 2017 Jan 5;794:61-68
pubmed: 27832944
J Vet Med Sci. 2014 Mar;76(3):313-21
pubmed: 24189580
J Surg Res. 2016 Jan;200(1):365-73
pubmed: 26265382
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
Nat Med. 2004 Dec;10(12):1379-83
pubmed: 15516929
BMC Bioinformatics. 2006 Jul 12;7:339
pubmed: 16836757
Nature. 1998 Jan 22;391(6665):410-3
pubmed: 9450761
J Cereb Blood Flow Metab. 2005 Jan;25(1):30-40
pubmed: 15678110
J Immunol. 2000 Jun 15;164(12):6509-19
pubmed: 10843709
Front Pharmacol. 2019 Mar 29;10:297
pubmed: 31024297
J Neurochem. 2007 Jul;102(2):365-77
pubmed: 17437550
PLoS One. 2011;6(6):e19923
pubmed: 21698148
J Physiol Pharmacol. 2014 Feb;65(1):67-74
pubmed: 24622831
Cerebrovasc Dis. 2014;38(1):1-9
pubmed: 25116305
J Transl Med. 2016 Apr 27;14(1):105
pubmed: 27118048
Drug Des Devel Ther. 2015 Jul 02;9:3445-54
pubmed: 26170628
Biochim Biophys Acta. 1979 Jan 4;582(1):67-78
pubmed: 760819
PLoS One. 2010 Dec 23;5(12):e15782
pubmed: 21203422
Front Neurosci. 2018 Dec 10;12:888
pubmed: 30618542
Anal Biochem. 1972 Jun;47(2):389-94
pubmed: 4556490